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Pharmaceutical composition for reducing blood sugar and preparation method thereof

A composition and blood sugar-lowering technology, which can be applied in drug combinations, pharmaceutical formulas, plant raw materials, etc., and can solve problems that have not been reported in the literature

Inactive Publication Date: 2013-08-14
BEIHUA UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] After searching, there is no literature report on the preparation of hypoglycemic drugs with the active ingredients of ginseng and eleuthero

Method used

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  • Pharmaceutical composition for reducing blood sugar and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] Weigh 300g of dried ginseng, add 1 to 2 times the amount of 50% ethanol to soak for 1 hour, use ultrasonic extraction for 1 to 3 hours, filter and collect the filtrate; concentrate the filtrate with a rotary evaporator, collect the concentrate, let it cool, add 2-3 times the amount of water and stirred, let it stand at room temperature for 24 hours, precipitated, filtered or centrifuged to take the precipitate, heated the precipitate in a watch glass, removed ethanol and water, until there was no alcohol smell, and obtained the ginseng alcohol extract; The ginseng alcohol extract was subjected to 150 μm reversed-phase chromatography, and gradient elution was carried out with methanol / water (V / V, 0:10-10:0) as the mobile phase, and the collected separated components were detected by reversed-phase thin-layer chromatography. Separate components with the same composition were combined and concentrated to obtain ten separate components from F1 to F10. F2 (IC 50 =12.5μg / L) ...

Embodiment 2

[0027] Weigh 400g of dried ginseng, add 1 to 2 times the amount of 50% ethanol to soak for 1 hour, use ultrasonic extraction for 1 to 3 hours, filter and collect the filtrate; concentrate the filtrate with a rotary evaporator, collect the concentrate, let it cool, add 2-3 times the amount of water and stirred, let it stand at room temperature for 24 hours, precipitated, filtered or centrifuged to take the precipitate, heated the precipitate in a watch glass, removed ethanol and water, until there was no alcohol smell, and obtained the ginseng alcohol extract; The ginseng alcohol extract was subjected to 150 μm reversed-phase chromatography, and gradient elution was performed with methanol / water (V / V, 0:10-10:0) as the mobile phase, and the collected separated components were detected by reversed-phase thin-layer chromatography. Separate components with the same composition were combined and concentrated to obtain ten separate components from F1 to F10. F2 (IC 50 =12.5μg / L) an...

Embodiment 3

[0030] According to the conventional method of pharmacy, the dry powder prepared in Example 1 or 2 can be added with one or more pharmaceutically acceptable Carriers or excipients are mixed to prepare various conventional dosage forms suitable for gastrointestinal administration. For example, the dry powder prepared above is aseptically filled into capsules according to conventional methods to obtain the pharmaceutical composition of the present invention in the form of capsules. The pharmaceutical composition of the present invention may be formulated into tablets, capsules, pills, powders, suppositories and solutions and suspensions according to methods known in the pharmaceutical industry. Among them, capsules and tablets suitable for gastrointestinal administration are preferred. When preparing dosage forms suitable for oral administration, sucrose, lactose, galactose, corn starch, gelatin, microcrystalline cellulose, carboxymethyl cellulose, etc. can be used as carriers ...

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Abstract

The invention discloses a pharmaceutical composition for reducing blood sugar and a preparation method thereof. The method comprises a step of adding one or more pharmaceutically acceptable carriers or excipients to mix after mixing the components, namely ginseng and slender acanthopanax. The pharmaceutical composition for reducing blood sugar is applied to medicaments for preventing diabetes mellitus, adiposis and complications thereof. The pharmaceutical composition not only can be applied to an inhibitor of protein tyrosine phosphatase IB(PTPIB) and an insulin sensitizer for treating various diabetes mellituses, adiposis and other complications caused thereby.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicine, and provides a blood sugar-lowering pharmaceutical composition and a preparation method. Multiple in vitro protein tyrosine phosphatase 1B inhibition experiments show that the composition can significantly inhibit PTP1B activity, and can be used in the preparation of medicines for diabetes, obesity and complications. technical background [0002] At present, diabetes is often divided into two types: insulin-dependent (IDDM, type 1 diabetes) and non-insulin-dependent (NIDDM, type 2 diabetes), of which type 2 diabetes accounts for 90% of diabetes. WHO predicts that the number of people with diabetes will rise from 135 million in 1995 to 300 million by 2025 due to aging population, obesity, unhealthy diet and inactive lifestyle. [0003] Type 2 diabetes is characterized by resistance to the action of insulin in insulin-sensitive tissues such as skeletal muscle, liver, and adipo...

Claims

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Application Information

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IPC IPC(8): A61K36/258A61P3/10A61P3/04
Inventor 崔龙杜培革王喜斌李娜李佳琳张南马坤
Owner BEIHUA UNIV
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