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Compound medicine prepn for treating diabetes and its prepn process

A compound preparation and a technology for diabetes, which are applied in the field of compound preparations for the treatment of diabetes and their preparation, and in the field of traditional Chinese medicine compound preparations, can solve problems such as adverse side effects and those with multiple complications are not suitable for use, achieve high-efficiency active ingredients, and delay diabetic vascular disease. , the effect of lowering blood sugar

Inactive Publication Date: 2006-11-08
SHANGHAI UNIV OF T C M
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Oral hypoglycemic drugs are mainly treated with western medicine. However, western medicine has adverse side effects on the cardiovascular, liver and kidney of diabetic patients, and it is not suitable for people with multiple complications.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] Proportion according to the group: Coptidis rhizome 50%, rhubarb 15%, cinnamon 2.8%, take Coptidis medicinal material, soak in 50% ethanol for 40 minutes, extract for 2 hours, reflux 3 times, recover ethanol from the extract, concentrate, dry and grind into fine powder . Add rhubarb with ultra-fine powder particle size of 10 μm and cinnamon with ultra-fine powder particle size of 12 μm by internal addition method, mix the three medicines evenly, add L-hydroxypropyl cellulose and magnesium stearate, mix and granulate, mix well, and press into tablets , coated.

Embodiment 2

[0034] Proportion according to the group: Coptidis 60%, rhubarb 22%, cinnamon 3.5%, take Coptidis medicinal material, soak in 50% ethanol for 40 minutes, extract for 2 hours, reflux 3 times, recover ethanol from the extract, concentrate, dry and grind into fine powder . Add rhubarb with ultra-fine powder particle size of 30 μm and cinnamon with ultra-fine powder particle size of 35 μm by internal addition method, mix the three medicines evenly, add L-hydroxypropyl cellulose and magnesium stearate, mix and granulate, mix well, and press into tablets , coated.

Embodiment 3

[0035] Embodiment 3 clinical treatment senile diabetes mellitus

[0036] 1. Case selection and grouping

[0037] (1) Case selection:

[0038] Select 74 elderly diabetic patients (regardless of the length of medical history, aged over 50 years old, and type 2 diabetic patients) who have received western medicine hypoglycemic drugs,

[0039] (2) The cases were divided into three groups: A, B and C.

[0040] Group A (single serving preparation of the present invention): 14 examples (4 examples for men, 10 for women),

[0041] Group B (preparation of the present invention combined with western medicine): 29 cases (12 cases of males and 17 cases of females)

[0042] Group C (western medicine group): 31 cases (7 males, 24 females)

[0043] The average age was 60 years old, and the average disease duration was 7 years.

[0044] 2. Observation and treatment

[0045] (1) Observation method: Before taking the medicine, the patient is required to check blood sugar and blood lipids,...

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Abstract

The invention belongs to the field of traditional Chinese medicines, and in particular relates to a compound preparation for treating diabetes containing Chinese medicines such as Coptidis Rhizoma and a preparation method thereof. The present invention adopts Chinese medicinal materials Coptis rhubarb, rhubarb and cinnamon as the main medicine, together with auxiliary materials; extracts, refluxes, dries and pulverizes Coptis chinensis by soaking in ethanol, adds superfine powdered rhubarb and cinnamon, mixes, compresses tablets, and coats the present invention. Compound preparations for the treatment of diabetes. The results of animal experiments and clinical use show that it can lower blood sugar and delay the occurrence of diabetic vascular disease while lowering blood sugar. It is convenient to take and has no toxic and side effects when taken for a long time. The preparation method of the invention can efficiently retain the active ingredients in the medicinal materials, simplify the preparation of traditional Chinese medicine preparations, protect the environment, and facilitate the operation of large-scale production.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicines, and relates to a compound preparation of traditional Chinese medicines, in particular to a compound preparation for treating diabetes containing Chinese medicines such as Coptidis Rhizoma and a preparation method thereof. Background technique: [0002] With the improvement of people's living standards and the aging of the population, the incidence of diabetes is increasing year by year. At present, the incidence of diabetes in our country is 1-2%, and it can be as high as 12% among the elderly. According to the survey results of world population and prevalence in 1994, it is estimated that the total number of type 2 diabetes patients in the world is nearly 100 million, which may reach 157 million by 2000 and 216 million by 2010. In 1996, the International Diabetes Committee revised the diagnostic criteria of diabetes, from the original diagnostic criteria of fasting blood glucose ≥140...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/718A61K36/708A61K36/54A61P3/10
Inventor 宋菊敏张宁柯雪帆毛良金若敏叶福嫒袁秀荣吴倩毛泉明施建玲张钰泉闫记灵王磊刘小美
Owner SHANGHAI UNIV OF T C M
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