Targetted polypeptide for specificity of liver cancer blood vessel

Abstract

A liver cancer blood vessel specific target polypeptide LCI-X7 able to specific binding with liver cancer blood vessel is extracted from the naked mouse model of human liver cancer by the showing technique of phage random peptide library in body and microscopic laser cutting technique. It provides important theory and practical basis for the diagnosis to liver cancer transfer recurrence and target therapy.

Description

technical field

[0001] The invention belongs to the field of biotechnology, relates to protein polypeptides, in particular to a polypeptide that can specifically bind to blood vessels of liver cancer tumors. Background technique

[0002] my country is a high-incidence area of ​​liver cancer in the world. According to statistics, about 200,000 people die of liver cancer every year, accounting for about half of the global liver cancer deaths. Modern medicine has conducted scientific research on liver cancer for more than a hundred years. Although many achievements have been made, the overall 5-year survival rate of liver cancer patients is still only about 3%. The biggest obstacle to improving the prognosis of liver cancer is its extremely high invasion and metastasis. Even with radical surgical resection, 50% of patients will develop metastasis or recurrence within 5 years. Therefore, in-depth study of the internal mechanism of liver cancer metastasis and recurrence and the ...

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