Method for analyzing beta-cyclodextrin clathrate compound by Fourier infrared spectrum method

A technology of cyclodextrin inclusion compound and infrared spectroscopy, which is applied in the field of Fourier infrared spectroscopy to analyze β-cyclodextrin inclusion compound, can solve the problems of difficult quantitative analysis, poor reproducibility, different principles and methods, etc. To achieve the effect of large amount of information

Inactive Publication Date: 2005-03-02
JIANGXI NORMAL UNIV
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Problems solved by technology

The DTA method is affected by many factors, the reproducibility is poor, it is difficult to quantitatively analyze, and it is time-consuming; for example, it takes 35-70 minutes at a heating rate of 5-10°C / min to 350°C
In addition, during 1994-2004, no report was found in China that independently used infrared spectroscopy but combined with other methods to analyze and verify β-cyclodextrin inclusion compound, which is completely different from the principle and method of the present invention.

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  • Method for analyzing beta-cyclodextrin clathrate compound by Fourier infrared spectrum method
  • Method for analyzing beta-cyclodextrin clathrate compound by Fourier infrared spectrum method
  • Method for analyzing beta-cyclodextrin clathrate compound by Fourier infrared spectrum method

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Embodiment Construction

[0051] 1. Analysis principle

[0052] β-Cyclodextrin is a hollow cylindrical compound composed of 7 glucosyl groups connected by 1,4 glycosidic linkages. It has a special cage structure with non-polar hydrophobic cavities in the cage, making it a host to contain various A guest molecule of comparable size.

[0053] The guest molecule fills the hole through inclusion, and the hole also creates space constraints on the guest molecule, hindering its free vibration. According to the principle of infrared spectroscopy, when the molecular vibration changes with the dipole moment, the vibration of the dipole will generate electromagnetic waves, which interact with the incident electromagnetic waves to produce light absorption. The intensity of infrared absorption is proportional to the transition probability, and it essentially depends on the magnitude of the dipole moment change during vibration:

[0054] Probability of transition ∝|μ ab | 2 Eo 2

[0055] Where Eo is the electric field...

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Abstract

The invention discloses a method of analyzing beta-clathrate by infrared spectrum method, comprising analytical principle, analytical method and step and result processing three main parts. Infrared absorption intensity of beta-clathrate objective molecule decreases notably after compound is discovered, called clathrate decresing infrared effect, which is the base of using FT-IR to analyze beta-clathrate. By measuring infrared spectrum of clathrate and nonclathrate and comparing position, form, attribution of their absorption peak, especially calculating change of absorption intensity, clathrate can be detected quantitatively or qualitatively. The invention has the advantages that it is simple, fast and visual that whether or not clathrate can be detected, has large amount of information. It is a novel and useful tool for researching and analyzing beta-clathrate, which not only owns, new area of research application, but also has particle use value in scientific research and production.

Description

Technical field [0001] The invention relates to a method for analyzing β-cyclodextrin inclusion compounds, in particular to a method for analyzing β-cyclodextrin inclusion compounds by Fourier infrared spectroscopy. Background technique [0002] β-Cyslodextrin (β-Cyslodextrin, abbreviated β-cyclodextrin) has a special cage structure, which makes it can be used as a host to contain various guest molecules of comparable size. Inclusion can change the physical and chemical characteristics of the guest molecule, such as the state and stability. In addition, β-cyclodextrin is non-toxic. Therefore, inclusion compounds formed by β-cyclodextrin with drugs and perfume molecules are increasingly widely used in pharmaceutical, food and other industries. in. The analysis and determination of β-cyclodextrin inclusion compound is an important link to improve the production process and ensure product quality. At present, thermal analysis techniques such as DTA (differential thermal), DSC (diffe...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N21/17G01N21/3563G01N21/59
Inventor 刘华卿
Owner JIANGXI NORMAL UNIV
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