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Method for analyzing beta-cyclodextrin clathrate compound by Fourier infrared spectrum method

A technology of cyclodextrin inclusion compound and infrared spectroscopy, which is applied in the field of B-cyclodextrin inclusion compound analysis by Fourier infrared spectroscopy, can solve the problems of difficult quantitative analysis, poor reproducibility, time-consuming, etc., and achieve information A large amount of effect

Inactive Publication Date: 2006-07-26
JIANGXI NORMAL UNIV
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Problems solved by technology

The DTA method is affected by many factors, the reproducibility is poor, it is difficult to quantitatively analyze, and it is time-consuming; for example, it takes 35-70 minutes at a heating rate of 5-10°C / min to 350°C
In addition, during 1994-2004, no report was found in China that independently used infrared spectroscopy but combined with other methods to analyze and verify β-cyclodextrin inclusion compound, which is completely different from the principle and method of the present invention.

Method used

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  • Method for analyzing beta-cyclodextrin clathrate compound by Fourier infrared spectrum method
  • Method for analyzing beta-cyclodextrin clathrate compound by Fourier infrared spectrum method
  • Method for analyzing beta-cyclodextrin clathrate compound by Fourier infrared spectrum method

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Embodiment Construction

[0051] 1. Analysis principle

[0052] β-cyclodextrin is a hollow cylindrical compound composed of 7 glucose groups connected by 1, 4 glycosidic bonds. A guest molecule of comparable size.

[0053] The guest molecules fill the holes through inclusion, and the holes also produce steric constraints on the guest molecules, hindering their free vibration. According to the principle of infrared spectroscopy, when the molecular vibration is accompanied by the change of the dipole moment, the vibration of the dipole will generate electromagnetic waves, which interact with the incident electromagnetic waves to produce light absorption. The infrared absorption intensity is proportional to the transition probability, which essentially depends on the change of the dipole moment during vibration:

[0054] Transition probability ∝|μ ab | 2 Eo 2

[0055] In the formula, Eo is the electric field vector of the infrared electromagnetic wave;

[0056] mu ab is the transition dipole momen...

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Abstract

The invention discloses a method of analyzing beta-clathrate by infrared spectrum method, comprising analytical principle, analytical method and step and result processing three main parts. Infrared absorption intensity of beta-clathrate objective molecule decreases notably after compound is discovered, called clathrate decresing infrared effect, which is the base of using FT-IR to analyze beta-clathrate. By measuring infrared spectrum of clathrate and nonclathrate and comparing position, form, attribution of their absorption peak, especially calculating change of absorption intensity, clathrate can be detected quantitatively or qualitatively. The invention has the advantages that it is simple, fast and visual that whether or not clathrate can be detected, has large amount of information. It is a novel and useful tool for researching and analyzing beta-clathrate, which not only owns, new area of research application, but also has particle use value in scientific research and production.

Description

technical field [0001] The invention relates to an analysis method for B-cyclodextrin inclusion compound, in particular to a method for analyzing B-cyclodextrin inclusion compound by Fourier infrared spectroscopy. Background technique [0002] 3-cyclodextrin (β-Cyslodextrin, abbreviated as β-cyclodextrin) has a special cage structure, so that it can be used as a host to include various guest molecules of comparable size. Inclusion can change the physical and chemical characteristics of the state and stability of the guest molecule, and β-cyclodextrin is non-toxic, so the inclusion complex formed by β-cyclodextrin and drug and spice molecules is increasingly widely used in pharmaceutical, food and other industries middle. The analysis and determination of β-cyclodextrin inclusion complex is an important link to improve the production process and ensure product quality. At present, methods such as thermal analysis techniques DTA (differential heat), DSC (differential display...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N21/17G01N21/35G01N21/59G01N21/3563
Inventor 刘华卿
Owner JIANGXI NORMAL UNIV
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