Accessible assay device and method of use

A technology for analyzing membranes and flow analysis, which is applied in the field of analysis and measurement, and can solve problems such as high energy of magnets

Inactive Publication Date: 2005-09-21
QUANTUM DESIGN
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

In these devices, however, the magnets require higher energy because the analyte placement spacing must be wide enough to accommodate thicker analytical devices

Method used

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  • Accessible assay device and method of use
  • Accessible assay device and method of use
  • Accessible assay device and method of use

Examples

Experimental program
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Embodiment Construction

[0034] A particular advantage of the present invention is that the sensitivity of the device is greatly improved over known lateral flow methods. It also provides a method for rapid detection of the assay area in the test strip. In addition, since the detector can access the test strip from the side of the test strip rather than from the end, the gap between the detector elements is relatively small. This is because the gap between the detector elements is not necessarily large to accommodate thicker sample pads or wicking pads, whereas larger gaps are required to accommodate thicker samples if the test strip is inserted lengthwise into the detector pads and wicking pads. Therefore, in the present invention, the electromagnet requires less power than the end-loading detector.

[0035] The use of magnetic particles has several advantages over the use of colored particles or other optical indicators known in the art. Linearity is an advantage here because magnetic detection i...

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Abstract

An assay test strip(10) and cassette(30). The test strip is positioned in a housing shaped and configured to allow a detector to access the test strip from the side, rather than from the lengthwise axis of the test strip. The housing may contain one or more test strips which may also be disposed on one or more surfaces of the housing. Preferably, the housing is generally C-shaped with the test strip spanning the space between the two arms of the C-shape. The housing is sealed to protect both the operator and instrument from possible contamination. The test strip is preferably embedded with paramagnetic particles and process chemistry specific for a particular application. Quantitative analysis may be accomplished using a magnetic reader device. In additional embodiments, detection is accomplished by visual means.

Description

technical field [0001] The present invention relates generally to analytical assays and, in particular, to a side-flow analytical device having an improved detection inlet. Background technique [0002] Various chromatographic (chromatographic) immunoassay techniques have been used for many years. Among others, tests that can be performed using such chromatographic systems are immunoassays (immunoassays), which depend on specific interactions between antigens or haptens and corresponding antibodies. Immunoassays have been used for some time as a method of testing for the presence or quantity, or both, of clinically important molecules. The immune-based latex agglutination test for the detection of factors associated with rheumatoid arthritis was used as early as 1956 (Singer et al., Am.J.Med. 22: 888-892 (1956)). [0003] In many analytical systems for the detection of analytes, especially analytes of biological interest, chromatographic analysis systems are employed. Am...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N33/558
CPCG01N33/558Y10T436/25375
Inventor 罗纳德·T·拉博尔德兰德尔·N·塔夫戴维·M·普拉特
Owner QUANTUM DESIGN
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