Soft capsule of 'Sheng Mai' and method for preparing same

A soft capsule and pulse-generating technology, which is applied in capsule delivery, pharmaceutical formula, medical preparations containing active ingredients, etc., can solve the problems of poor patient compliance, large amount of excipients, and increased dosage, and achieve fast absorption in the body, loading The effect of reasonable dosage and short disintegration time limit

Inactive Publication Date: 2006-12-20
江西欧氏药业有限责任公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Obviously, in order to obtain a stable content, the applicant used the method of simply increasing the dosage of the matrix. The negative effect is that the dosage is increased. On the one hand, the patient’s compliance is poor, and on the other hand, the excessive dosage of excipients will bring unforeseen Adverse reactions

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] Embodiment 1, extract and prepare the active ingredient of Shengmai Soft Capsule

[0031] Prescription: Codonopsis 300g, Ophiopogon japonicus 200g, Schisandra 100g

[0032] The twice prescription amount of the above three herbs is 1200g, add 10 times the amount of water to decoct twice, the first time is 2.0 hours, the second time is 1.5 hours, combine the decoction, filter, the filtrate is concentrated to about 600ml, let it cool, add ethanol 1200ml, left for 24 hours, filtered, the filtrate was concentrated under reduced pressure to a clear paste with a relative density of 1.30 (60-65°C), dried, and pulverized to obtain about 200g of the active ingredient.

Embodiment 2

[0033] Embodiment two, preparation suspending agent oil-wax mixture

[0034] Take 200g of beeswax, 600g of hydrogenated coconut oil, and 200g of hydrogenated vegetable oil, heat to 80°C to melt to obtain an oil-wax mixture, stir well and let cool.

Embodiment 3

[0035] Embodiment three, preparation soft capsule material

[0036] Preparation of capsule material: Take 5000g of gelatin, 4500g of water, heat to 70°C, take 1750g of glycerin, 15g of methyl paraben, appropriate amount of pigment, stir, vacuumize for 1 hour, mix with the above gelatin / water, keep it overnight at 70°C .

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PUM

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Abstract

The invention relates to a soft capsule for restoring pulse beat and method of preparation, wherein the contents include active constituent of codonopsis pilosula, Tween, Span, poloxamer 188, right amount of vegetable oil or suspension auxiliary agent by the weight ratio of 1:0.15-0.30:0.004-0.014.

Description

technical field [0001] The invention relates to a new dosage form of Shengmai granule (Dangshen prescription), Shengmai soft capsule and a preparation method thereof. Background technique [0002] The Shengmai Drink (Dangshen Fang) and Shengmai Granules (Dangshen Fang) appearing and sold on the market are derived from the famous ancient Chinese medical book "Debates on Internal and External Injuries". Qi produces fluid, combined with Ophiopogon japonicus to benefit yin and clear away heat; Schisandra tonifies the heart, restrains the lungs and stops sweating, all of which are adjuvant drugs. Comprehensive prescription, tonifying qi and yin, suppressing sweat and promoting pulse. Codonopsis Codonopsis is to replenish Qi and rejuvenate the pulse, nourish yin and promote body fluid. It is used for deficiency of both Qi and Yin, palpitation, shortness of breath, slight pulse and spontaneous sweating. Clinically, it has been proved that the prescription i...

Claims

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Application Information

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Patent Type & AuthorityApplications(China)
IPC IPC(8): A61K36/889A61K9/48A61P9/00
Inventor赵凯苑洪忠肖宝华
Owner江西欧氏药业有限责任公司