Isolated human Ras-like proteins, nucleic acid molecules encoding these human Ras-like proteins, and uses thereof

a technology of ras-like proteins and nucleic acids, applied in the field of ras-like proteins, can solve the problems of high diversity and complexity of the rab family

Inactive Publication Date: 2005-09-22
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

These novel Ras-like proteins and their encoding sequences serve as valuable targets for therapeutic modulation and diagnostic markers, enabling the development of treatments for inflammation, cancer, and disorders associated with cell proliferation and apoptosis, and providing tools for detecting genetic mutations and protein expression levels.

Problems solved by technology

Different Rab proteins are presumed to control different steps in membrane traffic, leading to a high level of diversity and complexity within the Rab family (Chavrier et al., Mol Cell Biol 1990 Dec.

Method used

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  • Isolated human Ras-like proteins, nucleic acid molecules encoding these human Ras-like proteins, and uses thereof
  • Isolated human Ras-like proteins, nucleic acid molecules encoding these human Ras-like proteins, and uses thereof
  • Isolated human Ras-like proteins, nucleic acid molecules encoding these human Ras-like proteins, and uses thereof

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Embodiment Construction

[0033] General Description

[0034] The present invention is based on the sequencing of the human genome. During the sequencing and assembly of the human genome, analysis of the sequence information revealed previously unidentified fragments of the human genome that encode peptides that share structural and / or sequence homology to protein / peptide / domains identified and characterized within the art as being a Ras-like protein or part of a Ras-like protein and are related to the Rab subfamily. Utilizing these sequences, additional genomic sequences were assembled and transcript and / or cDNA sequences were isolated and characterized. Based on this analysis, the present invention provides amino acid sequences of human Ras-like protein polypeptides that are related to the Rab subfamily, nucleic acid sequences in the form of transcript sequences, cDNA sequences and / or genomic sequences that encode these Ras-like protein polypeptide, nucleic acid variation (allelic information), tissue distri...

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Abstract

The present invention provides amino acid sequences of polypeptides that are encoded by genes within the human genome, the Ras-like protein polypeptides of the present invention. The present invention specifically provides isolated polypeptide and nucleic acid molecules, methods of identifying orthologs and paralogs of the Ras-like protein polypeptides, and methods of identifying modulators of the Ras-like protein polypeptides.

Description

FIELD OF THE INVENTION [0001] The present invention is in the field of Ras-like proteins that are related to the Rab subfamily, recombinant DNA molecules and protein production. The present invention specifically provides novel Ras-like protein polypeptides and proteins and nucleic acid molecules encoding such peptide and protein molecules, all of which are useful in the development of human therapeutics and diagnostic compositions and methods. BACKGROUND OF THE INVENTION [0002] Ras-like proteins, particularly members of the Rab subfamilies, are a major target for drug action and development. Accordingly, it is valuable to the field of pharmaceutical development to identify and characterize previously unknown members of this subfamily of Ras-like proteins. The present invention advances the state of the art by providing a previously unidentified human Ras-like proteins that have homology to members of the Rab subfamilies. [0003] Ras Protein [0004] Ras proteins are small regulatory G...

Claims

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Application Information

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Patent Type & AuthorityApplications(United States)
IPC IPC(8): A61K38/00C07K14/47
CPCC07K14/47A61K38/00
InventorMERKULOV, GENNADYDI FRANCESCO, VALENTINABEASLEY, ELLEN
OwnerAPPLERA