Methods and compositions for treating platelet-related disorders

a technology of platelet-related disorders and compositions, applied in the direction of drug compositions, aerosol delivery, metabolic disorders, etc., can solve the problems of illness and death in adults, and achieve the effects of reducing the platelet count, enhancing the regression, and inhibiting the development, progression or propagation of the condition

Inactive Publication Date: 2005-10-13
BIOVASCULAR INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

[0005] The invention in a broad aspect involves the surprising discovery that subjects, including those with normal levels of circulating platelets, can unexpectedly derive medical benefit from a reduction in platelet count to below normal levels, without serious adverse consequences as a result of the platelet count reduction. The benefit may be proportional or correlative to the reduction in platelet count in a broad safety range. Thus in situations where...

Problems solved by technology

Conditions resulting from thrombotic or thromboembolic events are the leading causes of illness and death in adults in western civilization.
Notwithstanding the effor...

Method used

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Examples

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Embodiment Construction

[0029] Unexpectedly, the invention involves the discovery that treating human subjects, especially those who do not have a hematological proliferative disorder, to induce a lower platelet count (such as to low normal levels or in some preferred instances to below normal levels) can have desirable medical benefit without significant adverse side effects.

[0030] The invention is premised in part on the discovery that a reduction in platelet count in a subject, such as for example to low normal and more preferably below normal levels, reduces the risk of a vaso-occlusive event such as a thrombotic event in the subject without significant adverse side effects. As used herein, a vaso-occlusive event is an event that is characterized by or results in a decrease in the internal diameter of blood vessels either locally or systemically to an extent which impedes blood flow in a subject and which for the purposes of the invention is of a pathological nature. Thus, a vaso-occlusive event embra...

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Abstract

Pharmaceutical preparations comprising one or more agents that reduce the number of circulating platelets to low normal or below normal levels formulated in a delivery system are provided. The pharmaceutical preparations are useful in the prophylactic and therapeutic treatment of subjects for the purpose of inhibiting vaso-occlusive events, including embolism, by reducing the number of circulating platelets to low normal to below normal levels.

Description

RELATED APPLICATIONS [0001] This application is a continuation of copending U.S. patent application Ser. No. 10 / 603,401, filed Jun. 25, 2003, to Stephen R. Hanson, entitled “METHODS AND COMPOSITIONS FOR TREATING PLATELET-RELATED DISORDERS,” which is a continuation of U.S. patent application Ser. No. 09 / 666,223, filed Sep. 21, 2000, to Stephen R. Hanson, entitled “METHODS AND COMPOSITIONS FOR TREATING PLATELET-RELATED DISORDERS,” now U.S. Pat. No. 6,585,995, which issued Jul. 1, 2003, and which claims benefit of priority under 35 U.S.C. § 19(e) to U.S. provisional application Ser. No. 60 / 154,929 to Stephen R. Hanson, filed Sep. 21, 1999, entitled “METHODS AND COMPOSITIONS FOR TREATING PLATELET-RELATED DISORDERS.” The benefit of priority is claimed to each of these applications. The disclosure of each of these applications is incorporated by reference herein in its entirety.FIELD OF THE INVENTION [0002] The invention relates to methods and products for treatment and / or prevention of p...

Claims

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Application Information

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IPC IPC(8): A61K9/00A61K45/00A61K9/06A61K9/20A61K31/00A61K31/4365A61K31/519A61K31/60A61K31/616A61K31/726A61K38/16A61K38/36A61K38/48A61K38/49A61K45/06A61K47/28A61P3/06A61P7/02A61P9/10A61P9/12A61P9/14A61P11/00A61P13/12A61P27/14A61P43/00
CPCA61K9/1647A61K9/204A61K47/34A61K45/06A61K38/49A61K31/616A61K31/60A61K31/557A61K31/522A61K31/00A61K31/4365A61K31/4965A61K31/519A61K2300/00A61P11/00A61P13/12A61P27/14A61P3/06A61P43/00A61P7/02A61P9/10A61P9/12A61P9/14
Inventor HANSON, STEPHEN R.
Owner BIOVASCULAR INC
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