Closed-Loop Clot Lysis

Abstract

The present invention provides procedures and systems that use a closed-loop approach for directing ultrasound energy at a clot while monitoring blood flow and/or liquification of the clot tissue so as to allow automated and/or manual adjustments to various treatment parameters.

Description

CROSS-REFERENCE TO RELATED APPLICATIONS[0001]This application claims priority to and the benefits of U.S. provisional patent application Ser. No. 61 / 116,111, filed Nov. 19, 2008, the entire disclosure of which is incorporated be reference herein.TECHNICAL FIELD[0002]The present invention relates generally to systems and methods for performing noninvasive procedures using acoustic energy, and, more particularly, to systems and methods for focusing ultrasonic energy to treat thrombotic disease.BACKGROUND INFORMATION[0003]Tissue, such as a benign or malignant tumor or blood clot within a skull or other region of a patient's body may be treated invasively by surgically removing the tissue, or non-invasively by using effects of focused ultrasound. Both approaches may effectively treat certain localized conditions within the brain, but involve delicate procedures in which it is desired to avoid destroying or damaging otherwise healthy tissue. These treatments may not be appropriate for co...

AI Technical Summary

Benefits of technology

[0009]The present invention provides procedures and systems that facilitate non-invasive, focused clot lysis. In general, the technique uses a closed-loop approach such that immediate feedback is provided to an operator or to an automatic control system. One application directs ultrasound energy at the clot so as to cause it to become smaller (typically through liquefaction) while sparing adjacent tissue. During the application of the ultrasound, blood flow is monitored in the vicinity of the blocked vessel, or, in the case of hemorrhagic stroke, the liquefaction of the clot is monitored. For example, in some embodiments, images are taken of the area surrounding the clot and displayed to an operator so as to provide a real-time indication of blood flow in and/or around the affected blood vessel or the content of the hemorrhage (i.e., so

Problems solved by technology

Both approaches may effectively treat certain localized conditions within the brain, but involve delicate procedures in which it is desired to avoid destroying or damaging otherwise healthy tissue.

These treatments may not be appropriate for conditions in which diseased tiss

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