Pharmaceutical composition for inhibiting peritoneal dissemination
a technology of peritoneal cancer and pharmaceutical composition, which is applied in the direction of drug compositions, peptide/protein ingredients, instruments, etc., can solve the problems of unsatisfactory results of immunotherapy doses, uncompletely clarified regulation mechanisms of ctgf adhesion to cancer cells, etc., and achieve the effect of reducing the occurrence of peritoneal metastasis and peritoneal carcinoma recurren
Inactive Publication Date: 2010-12-30
NAT TAIWAN UNIV
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Benefits of technology
The present invention provides a pharmaceutical composition and a method for treating peritoneal dissemination and preventing peritoneal carcinoma recurrence using CTGF. The pharmaceutical composition includes CTGF or an active fragment thereof and can inhibit cancer cells from adhering to the peritoneal tissue, preventing peritoneal nodule formation and reducing the occurrence of peritoneal metastasis and carcinoma recurrence. The method involves measuring the expression of CTGF in the peritoneal tissue and comparing it to a reference amount to determine the risk of peritoneal dissemination or carcinoma recurrence. The invention also provides a screening method for identifying inhibitors of peritoneal dissemination and a method for administering CTGF to patients.
Problems solved by technology
However, immunotherapy dose not yet have a concrete result acceptable for everybody.
However, the regulation mechanism of CTGF adhering to cancer cells are not completely clarified.
Method used
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Embodiment Construction
[0041]The present invention will now be described more specifically with reference to the following Embodiments. It is to be noted that the following descriptions of preferred Embodiments of this invention are presented herein for purpose of illustration and description only; it is not intended to be exhaustive or to be limited to the precise form disclosed.
Pharmacological Experiments
[0042]1. Surgical Sampling and Immunohistological Staining
[0043]Subserosa (T3)- and perforating visceral peritoneum or peripheral organ (T4)-invasive colorectal cancer tissues from 136 consecutive patients were included at National Taiwan University Hospital during the period from December 1993 to July 1999. All patients underwent complete surgical resection, and their clinical and pathological data were available at the same time. Patients with histological proven peritoneal metastasis of colorectal cancer (CRC) diagnosed at the first presentation were defined as synchronous peritoneal seeding. All pat...
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Abstract
A pharmaceutical composition for treating or preventing peritoneal dissemination is provided. The pharmaceutical composition includes an effective dose of connective tissue growth factor (CTGF) and an acceptable receptor thereof.
Description
FIELD OF THE INVENTION[0001]The present invention relates to a pharmaceutical composition. In particular, the present invention relates to a pharmaceutical composition for inhibiting peritoneal dissemination.BACKGROUND OF THE INVENTION[0002]Peritoneal metastasis mostly originates from the tumors in the neighboring digestive system and organs, such as intestine, stomach, liver, pancreas, etc. Tumor cells accumulate and adhere abundantly on the peritoneum through blood or the lymph node after falling into peritoneal cavity, but do not invade other substantial organs (such as spleen, uterus and ovaries) directly. These tumor cells adhere on the surfaces of these organs, and will proliferate to invade these organs directly for a long time. This is a common phenomenon for cancers in the digestive tract of the peritoneal cavity. For instance, cancers include gastric cancer, small intestine cancer, colon cancer, rectal cancer, appendiceal cancer and pancreatic cancer. Certainly, there are ...
Claims
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IPC IPC(8): A61K38/18A61P35/00C12Q1/02
CPCA61K38/18G01N33/5011G01N33/57419G01N2800/54G01N33/57449G01N2333/475G01N2800/50G01N33/57446A61P35/00A61P35/04
Inventor KUO, MIN-LIANGLIN, BEEN-RENCHANG, CHENG-CHICHEN, CHIUNG-NINE
Owner NAT TAIWAN UNIV