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Biomarkers associated with pre-diabetes, diabetes and diabetes related conditions

a technology of prediabetes and biomarkers, applied in the direction of peptide/protein ingredients, metabolism disorders, instruments, etc., can solve the problems of imposing a major financial burden on the health system, increased risk of heart disease and diabetes, and higher prevalence of impaired glucose metabolism, so as to reduce the risk of developing

Inactive Publication Date: 2013-07-11
PROTEOMICS INT +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

The present invention provides a method of treating or reducing the risk of developing pre-Diabetes, Diabetes and / or a Diabetes related condition in a subject by administering an agent that changes the expression or levels of at least one biomarker in Table 1 or 2. This invention also provides the use of an agent adapted to change the expression or level of at least one biomarker in Table 1 or 2 for preparing a medication for treating or reducing the risk of developing pre-Diabetes, Diabetes and / or a Diabetes related condition.

Problems solved by technology

Worldwide there is an ever increasing population of patients with diabetes that are imposing a major financial burden on health systems.
Along with the rising rate of diabetes there is also a higher prevalence of impaired glucose metabolism, which is associated with an increased risk of heart disease and diabetes.
Given the increasing prevalence of obesity, it is likely that these figures underestimate future diabetes prevalence.
Over time, high blood glucose levels may damage blood vessels and nerves.
These complications of diabetes can cause damage to eyes, nerves and kidneys and increase the risk of heart attack, stroke, impotence and foot problems.
This damage can happen before an individual knows that they have diabetes if left undetected for a long time.
The reasons behind the complication of nephropathy in diabetes is complex, and includes the toxic effects of high glucose levels; elevated blood pressure; abnormal lipid levels and abnormalities of small blood vessels.

Method used

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  • Biomarkers associated with pre-diabetes, diabetes and diabetes related conditions

Examples

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example 1

Identification and Validation of Diabetes Biomarkers

1. Materials / Methods

A. Cohort Description

A.1. Fremantle Diabetes Study (Phase 1)

[0124]Rational: The FDS1 cohort comprised 1294 patients who had type 2 diabetes. Diabetic subjects with and without diabetic nephropathy were selected to give markedly different phenotypic presentations enabling the greatest difference in protein expression.

[0125]The Fremantle Diabetes Study (FDS) Phase I was a longitudinal observational study of diabetes care, control, complications and cost in patients from a stable postcode-defined urban community of 120,097 people. When Phase I was conceived in 1991, there were few published diabetes natural history data.

Study groups:Adults type 2 diabetics, Anglo-CeltsGroup 1:Normoalbuminuria (ACR: 0.57-1.53 mg / mmol)Group 2:Macroalbuminuia (ACR: 49.0-300.0 mg / mmol)Ages:33-84 yearsNumber of subjects:20 per group; 40 in totalSelection range:1294Protocol:EDTA tube, centrifuged within 4 hours, separated & stored at-80°...

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Abstract

Biomarkers for pre-Diabetes, Diabetes and / or a Diabetes related conditions, and methods of their use, including the biomarkers in Tables 1 and 2 such as peroxiredoxin-2, complement C1q subcomponent subunit B, sulfhydryl oxidase 1 and apolipoprotein A-IV.

Description

FIELD OF THE INVENTION[0001]The invention relates to biomarkers associated with pre-Diabetes, Diabetes and Diabetes related conditions, such as diabetic nephropathy, methods of using the biomarkers to determine the risk that an individual will develop pre-Diabetes, Diabetes and Diabetes related conditions, methods of screening a population to identify persons at risk for developing pre-Diabetes, Diabetes and Diabetes related conditions and drug targets for pre-Diabetes, Diabetes and Diabetes.BACKGROUND TO THE INVENTION[0002]Diabetes mellitus is a chronic disease and one of the major public health problems of our time. Worldwide there is an ever increasing population of patients with diabetes that are imposing a major financial burden on health systems. The prevalence of diabetes for all age-groups worldwide was estimated to be 2.8% in 2000 and 4.4% by 2030. The total number of people with diabetes is projected to rise from 171 million in 2000 to 366 million in 2030. In 2002 the prev...

Claims

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Application Information

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Patent Type & Authority Applications(United States)
IPC IPC(8): G01N33/68
CPCC12Q1/6883C12Q2600/158G01N33/6893G01N2333/4716G01N2333/775G01N33/6848G01N2333/908G01N2800/042G01N2800/347G01N2800/50G01N2333/90212C12Q1/26C12Q1/28A61P13/12A61P3/10
Inventor STOLL, THOMASBRINGANS, SCOTTWINFIELD, KAYECASEY, TAMMYDAVIS, WENDYPETERS, KIRSTENDAVIS, TIMOTHYLIPSCOMBE, RICHARD
Owner PROTEOMICS INT
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