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Calcium sequestration compositions and methods of treating skin pigmentation disorders and conditions

a technology of pigmentation disorders and compositions, applied in dermatological disorders, organic active ingredients, cosmetics, etc., can solve the problems of undesirable pigmentation patterns, many of these previous examples were not acceptable or limited in their efficacy in treating skin pigmentation, and the process of melanosome maturation and melanosome transfer is far less studied and understood. to achieve the effect of only minor skin irritation

Inactive Publication Date: 2016-02-04
NEOCUTIS
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

[0022]The compositions for treating, or ameliorating at least one symptom of, a skin pigmentation disorder or condition, in a subject in need thereof, are formulated for topical administration. By way of non-limiting example, the compositions of the invention can be in the form of a solution, an oil-in-water emulsion, a water-in-oil emulsion, a gel, an ointment, a patch, a paste, a liquid, a foam, a mousse, a spray, an aerosol, a triple emulsion, a nanoemulsion, a microemulsion, a hydrogel, a jelly, a dispersion, a suspension, and / or a tape. The compositions are stable, substantially free of calcium, do not cause an acnegenic / comedogenic response, and / or produce only minor skin irritation upon administration.

Problems solved by technology

However, the processes of melanosome maturation and melanosome transfer into the keratinocyte are currently far less studied and not yet understood.
However, melanogenesis and skin pigmentation can be disturbed or disorder, which may lead to undesirable pigmentation patterns.
Many of these previous examples were not acceptable or were of limited efficacy in treating skin pigmentation.
Most of these compounds have been described to address only a few steps of the multiple steps leading to melanin formation and ultimately skin pigmentation, which may result their limited efficacy.
In addition, many of these compounds have been found to be irritating to the skin and, therefore, undesirable for use.

Method used

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  • Calcium sequestration compositions and methods of treating skin pigmentation disorders and conditions
  • Calcium sequestration compositions and methods of treating skin pigmentation disorders and conditions
  • Calcium sequestration compositions and methods of treating skin pigmentation disorders and conditions

Examples

Experimental program
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Effect test

example 1

[0110]Exemplary compositions formulated in accordance with the present invention are presented in Table 19. These compositions serve as illustrative formulations which provide several of the advantageous features of the invention, namely, mildness to the skin after application with no or only limited skin irritancy; clearness and non-greasiness upon application (transparent) to face and other skin areas other than the palms and the soles; and quick-drying, particularly when the compositions are preferably formulated as water-in-oil formulations.

TABLE 19INGREDIENT% BYNO.PHASE(TRADE NAME)INCI DESIGNATIONSUPPLIERWEIGHT1ADEIONIZED WATERWATER (AQUA)63.3102ANA2EDTADISODIUM EDTAAKZO / DEWOLF0.1003AKELTROL CG-TXANTHAN GUMCP KELCO / 0.300UNIVAR4BLIPOWAX DCETEARYL ALCOHOLLIPO8.250CETEARETH-205BLIPO GMS 450GLYCERYL STEARATELIPO6.0006BCERAPHYL 230DIISOPROPYL ADIPATEISP SUTTON5.0007BDC TORAY FZ-3196CAPRYLYL METHICONEDOW CORNING / 3.000UNIVAR8BDC 200 FLUID 100 CSTDIMETHICONEDOW CORNING / 1.000UNIVAR9BLIP...

example 2

[0122]Additional compositions formulated in accordance with the present invention are presented in Table 20. Again, these compositions serve as illustrative formulations which provides the advantageous features of the invention, namely, mildness to the skin after application with no or only limited skin irritancy; clearness and non-greasiness upon application (transparent) to face and other skin areas other than the palms and the soles; and quick-drying, particularly when the compositions are preferably formulated as water-in-oil formulations.

TABLE 20INGREDIENT% BYNO.PHASE(TRADE NAME)INCI DESIGNATIONSUPPLIERWEIGHT1ADEIONIZED WATERWATER (AQUA)59.6802ANA2EDTADISODIUM EDTAAKZO0.1003AKELTROL CG-TXANTHAN GUMCP KELCO0.3004AELESTAB CPN ULTRA PURECHLORPHENESINCOGNIS0.3005APHENOXETOLPHENOXYETHANOLCLARIANT0.6006ASEPIWHITE MSHUNDECYLENOYLSEPPIC0.500PHENYLALANINE7ASODIUM GLYCEROPHOSPHATESODIUMDR. PAUL3.000(Ph. Eur. 6 Ed, Item# 500012045500)GLYCEROPHOSPHATELOHMANN8AL-LEUCINELEUCINEAJINOMOTO1.000...

example 3

[0137]Additional compositions formulated in accordance with the present invention are presented in Table 21. These compositions serve as illustrative formulations, which provide the advantageous features of the invention, namely, stability of the composition, mildness to the skin after application with no or only limited and acceptable skin irritancy; clearness and non-greasiness upon application (transparent) to face and other skin areas other than the palms and the soles; and quick-drying, particularly when the compositions are preferably formulated as water-in-oil formulations.

TABLE 21INGREDIENT% BYNO.PHASE(TRADE NAME)INCI DESIGNATIONWEIGHT1ADEIONIZED WATERWATER (AQUA)59.6802ANA2EDTADISODIUM EDTA0.1003AKELTROL CG-TXANTHAN GUM0.3004AELESTAB CPN ULTRA PURECHLORPHENESIN0.3005APHENOXETOLPHENOXYETHANOL0.6006ASEPIWHITE MSHUNDECYLENOYL PHENYLALANINE0.5007ASODIUM GLYCEROPHOSPHATE (Ph.SODIUM GLYCEROPHOSPHATE3.000Eur. 6 Ed, Item# 500012045500)8AL-LEUCINELEUCINE1.0009BCITRIC ACID 50% SOLUTI...

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Abstract

The present invention provides compositions containing one or more calcium sequestration agents and methods for topical application of such compositions to the skin to treat skin pigmentation disorders, such as melasma, post-inflammatory hyperpigmentation, pigmentation changes due to skin aging, or any other skin conditions related with normal such as skin of color or abnormal pigmentation such as hypo- or hyper-pigmentation in humans.

Description

RELATED APPLICATIONS[0001]This application is a continuation of U.S. patent application Ser. No. 12 / 688,107, filed Jan. 15, 2010 which claims priority to U.S. Ser. No. 61 / 145,325, filed Jan. 16, 2009, both of which are herein incorporated by reference in their entirety.FIELD OF THE INVENTION[0002]The invention relates generally to compositions containing one or more calcium sequestration agents and methods for topical application to the skin to treat skin pigmentation disorders, such as melasma, post-inflammatory hyperpigmentation, pigmentation changes due to skin aging, or any other skin conditions related with normal such as skin of color or abnormal pigmentation such as hypo- or hyper-pigmentation in humans.BACKGROUND OF THE INVENTION[0003]In humans, skin color arises from a complex series of cellular processes that are carried out within a group of cells known as melanocytes. Melanocytes are located in the lower part of the epidermis and their function is to synthesize a pigment...

Claims

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Application Information

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Patent Type & Authority Applications(United States)
IPC IPC(8): A61K8/55A61Q19/02
CPCA61Q19/02A61K8/55A61P17/00A61K8/066A61K31/6615A61K2121/00A61K2800/88
Inventor DREHER, FRANK
Owner NEOCUTIS
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