Treatment for Chemotherapy-Induced Peripheral Neuropathy

Abstract

The present invention provides methods and compositions for treating chemotherapy induced peripheral neuropathy. One embodiment of the present invention is directed to a method of treating chemotherapy induced peripheral neuropathy by administering to a patient in need at least one thiosemicarbazone compound.

Description

BACKGROUND OF THE INVENTION[0001]Chemotherapy-induced peripheral neuropathy (CIPN) is one of the most common, serious side effects that can lead to dose reductions or early discontinuation of chemotherapy, reducing the efficacy of cancer treatments. It can cause debilitating symptoms and also significantly impacts the patient's quality of life. An estimated 30 to 40 percent of cancer patients treated with chemotherapy experience CIPN.[0002]The peripheral nervous system (PNS) consists of sensory neurons running from stimulus receptors that inform the central nervous system (CNS) of the stimuli, and motor neurons running from the spinal cord to the effectors that take action. In CIPN, an anticancer drug could impair both sensory and motor functions. The symptoms usually start in the hands and / or feet and creep up the arms and legs. Sometimes it feels like a tingling or numbness. Other times, it's more of a shooting and / or burning pain or sensitivity to temperature. It can include shar...

AI Technical Summary

Benefits of technology

The present invention relates to a method of treating chemotherapy-induced peripheral neuropathy by administering a thiosemicarbazone compound or a composition containing it to a patient in need. The thiosemicarbazone compound can be administered in various ways such as intravenously, orally, or topically. The invention also includes methods of treating neuropathy using a compound of Formula I or an analogue thereof. Overall, the invention provides a novel method to treat a common side effect of chemotherapy.

Problems solved by technology

Chemotherapy-induced peripheral neuropathy (CIPN) is one of the most common, serious side effects that can lead to dose reductions or early discontinuation of chemotherapy, reducing the efficacy of cancer treatments.

It can cause debilitating symptoms and also significantly impacts the patient's quality of life.

CIPN can also lead to hearing loss, blurred vision and change in taste.

CIPN can make it difficult to perform normal day-to-day tasks like buttoning a shirt, sorting coins in a purse, or walking.

In addition, the motor neuron dysfunction manifest as cramps, difficulty with fine motor activities (e.g. writing or dialing a phone), gait disturbances, paralysis, spasms, tremors and weakness.

But these therapies have not demonstrated true efficacy for CIPN, and virtually all of the drugs to treat peripheral neuropathy carry side effects of their own.

Use of the anticancer drug cisplatin results in severe cell death of sensory neurons derived from dorsal root ganglia following increase in oxidative stress.

Oxidative stress is also found to impair the autonomic nervous system and manifests itself in symptoms such as hearing loss.

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