The present invention relates to
subtilase variants having a reduced tendency towards inhibition by substances present in eggs, such as
trypsin inhibitor type IV-0. In particular, the variants comprise at least one additional
amino acid residue between positions 42-43, 51-56, 155-161, 187-190, 216-217, 217-218 or 218-219 (in BASBPN
numbering). These
subtilase variants are useful exhibiting excellent or improved wash performance on egg stains when used in e.g. cleaning or detergent compositions, such as
laundry detergent compositions and dishwash composition, including automatic dishwash compositions. Also, isolated
DNA sequences encoding the variants, expression vectors, host cells, and methods for producing and using the variants of the invention. Further, cleaning and detergent compositions comprising the variants are disclosed.