The present invention discloses a medicinally and edibly homogenous sugar-lowering granule and a preparation method and an application thereof, and belongs to the technical field of medicines and health care. The medicinally and edibly homogenous sugar-lowering granule comprises the following raw materials in parts by weight: 20-30 parts of a radix astragali and licorice extract, 7-10 parts of pumpkin powder, 7-10 parts of sweet potato powder, 7-10 parts of bitter gourd powder and 40-60 parts of auxiliary materials. The preparation method is as follows: pumpkins, sweet potatoes and bitter gourds are respectively prepared into powder materials; radix astragali and licorice are mixed to be prepared into a radix astragali and licorice extract, the radix astragali and licorice extract is mixedwith the prepared pumpkin powder, sweet potato powder and bitter gourd powder, then soluble starch, maltodextrin, sodium citrate, potassium sorbate and xylitol are added, the materials are mixed evenly to prepare soft materials, and sieving and granulating, drying and granule-separating are conducted to obtain a finished product. The sugar-lowering granule has effects of supplementing qi, supplementing the kidneys, lowering sugar and alleviate symptom-complex of excessive eating, can meet demands for medicinal effects, has many use methods, can exert effectiveness of the medicines, also has food safety, and has advantages of being small in dosage, easy to carry, fast in absorption, stable in curative effects, etc.