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Drug coating-spraying method for drug eluting stent and spraying apparatus therefor

A technology of spraying device and inner stent, which is applied in the direction of human tubular structure devices, blood vessels, stents, etc., which can solve the problems of uneven spraying and high consumption of spraying materials, and achieve the goal of reducing surface roughness, saving paint, and reducing spraying dead ends Effect

Inactive Publication Date: 2008-02-27
CHONGQING UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The object of the present invention is to address the above-mentioned deficiencies and provide a drug-eluting intravascular stent spraying method and its spraying device. The device has a simple structure and solves the existing shortcomings of uneven spraying and high consumption of spraying materials.

Method used

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  • Drug coating-spraying method for drug eluting stent and spraying apparatus therefor
  • Drug coating-spraying method for drug eluting stent and spraying apparatus therefor

Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0045]The dexamethasone drug-eluting intravascular stent spraying method is carried out in the following steps:

[0046] (1) Select 316L stainless steel brackets, ultrasonically clean them in ethanol, acetone, and distilled water for 4 minutes, then dry them in a vacuum oven for 45 minutes at a drying temperature of 45°C, and finally irradiate them with ultraviolet light for 30 minutes for disinfection;

[0047] (2) Preparation of spray solution

[0048] After cleaning and disinfecting the stent, prepare a mixed solution of 15% polylactic acid, 70% acetone and 15% dexamethasone, heat the prepared solution to 30°C, stir with a magnetic stirrer for 40 minutes, and mix well;

[0049] (3) Spray drug coating

[0050] Add the prepared spraying solution into the solution bottle 5, the volume of the solution is 30 milliliters; turn on the high-pressure gas cylinder switch 8, and adjust the gas carrier rate of the flowmeter 7 to 0.3 liters / minute; turn on the switch of the adjustable-...

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Abstract

This invention is about a process for painting drug elution vas internal support and the painting apparatus. It is a process for painting cardiovascular support and the painting apparatus. This invention solves the problem of heterogeneous painting and great material consumption in current support. The painting preparation processes mainly contain cleaning, drying and spraying to prepare drug coating. The painting apparatus mainly contain: support, nozzle, solution bottle, plastic hose, flow instrument, high-pressure tank, nozzle, ultrasonic atomizer, adjustable rotary table and flume. The downside of the support strut connects with the adjustable rotary table; the solution bottle connects with high-pressure tank by the flow instrument, the ultrasonic atomizer, whose top connects with the solution bottle, is installed in the flume. The uniform drug coating is formed by painting ultrasonic nebulized aerosol fogdrop on the surface of the support of certain movement state. This invention can not only paint heterogeneously and decrease surface roughness of support, but also can greatly save painting material.

Description

technical field [0001] The invention relates to a method and a device for spraying a cardiovascular drug stent, in particular to a method for spraying a drug-eluting intravascular stent and a spraying device thereof. Background technique [0002] Since the advent of vascular balloon dilation surgery, the use of vascular stents to treat obstructive coronary artery disease has been the main development direction. However, in-stent restenosis may occur after stent implantation. After the stent is implanted, vascular intimal hyperplasia will first appear. The compression of the metal stent can activate platelets and macrophages. At the same time, cytokines and growth factors will also have an effect on the proliferation of smooth muscle cells. In addition, abnormal regulation of genes and metal The action of proteases, which in turn trigger cell proliferation, remodeling of the extracellular matrix, and migration of smooth muscle cells, combined to lead to severe in-stent reste...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/28A61L27/54A61F2/06A61F2/90
Inventor 王贵学罗来龙尹铁英侯延斌李彦李卫娜艾勇
Owner CHONGQING UNIV
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