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Dissolving degree detector for continuously detecting multiple component medicine

A dissolution tester technology, used in instruments, measuring devices, scientific instruments, etc., can solve the problems of measurement lag and single wavelength, and achieve the effect of reducing measurement errors, reducing light scattering, and increasing accuracy

Inactive Publication Date: 2009-01-28
JILIN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The technical problem to be solved by the present invention is: to overcome the above-mentioned shortcomings and deficiencies existing in the current commercial drug dissolution detector, design a new type of sample introduction system, fundamentally solve the problem of measurement lag, and make the operation convenient ,save time and energy
The UV-enhanced linear CCD array detector is used to realize simultaneous detection of multiple components and multiple wavelengths, which solves the problem that the current dissolution tester can only measure the dissolution rate of a single wavelength and a single component

Method used

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  • Dissolving degree detector for continuously detecting multiple component medicine
  • Dissolving degree detector for continuously detecting multiple component medicine
  • Dissolving degree detector for continuously detecting multiple component medicine

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0016] Example 1 The overall structure of the dissolution tester of the present invention for continuous determination of multi-component drugs.

[0017] See figure 1 , the overall structure of the present invention includes a sample introduction system 1 , an optical path system 2 , a spectroscopic detection system 3 , a computer system 4 and a round bottom beaker 19 .

[0018] The sampling tube 5 extracts the liquid medicine from the round-bottom beaker 19 of the dissolution apparatus, the liquid medicine flows through the sample introduction system 1, and the light emitted by the light source 10 is injected into the six channels of the sample introduction system 1 from the incident optical fiber 12 in the optical path system 2. A channel in the channel flow cell 8 is injected into the outgoing optical fiber 13 in the optical path system 2 after reacting with the liquid medicine in the flow cell 8 . After the light is emitted from the outgoing optical fiber 13, it is conver...

Embodiment 2

[0019] Example 2 The sample introduction system of the dissolution tester for continuous determination of multi-component drugs according to the present invention.

[0020] The sample introduction system 1 can be composed of six sampling tubes 5 , a six-channel peristaltic pump 7 , a stepper motor 9 , and a six-channel flow cell 8 . Among them, six sampling tubes 5 respectively extract liquid medicine from six round-bottom beakers 19 of the dissolution apparatus, pass through the peristaltic pump 7 , and enter corresponding channels in the six-channel flow cell 8 . The stepping motor 9 controls the movement of the six-channel flow cell 8 so that the six channels pass through the optical system 2 in sequence. Because the working principles of the six channels are exactly the same, figure 2 Only one of the channels is shown in the figure.

[0021] exist figure 2 Among them, one end has a sampling tube 5 with a microporous membrane, and one end with a micronull membrane dire...

Embodiment 3

[0022] Example 3 The optical path system of the dissolution detector for continuous determination of multi-component drugs of the present invention.

[0023] See image 3 , the optical path system 2 of the dissolution detector for continuous determination of multi-component drugs is composed of a light source 10 , a convex lens 11 , an incident optical fiber 12 , and an outgoing optical fiber 13 . The light emitted by the light source 10 is converged by the convex lens 11 and enters the incident optical fiber 12, and then enters one channel of the six-channel flow cell. After the light interacts with the liquid medicine in the channel, it is injected into the outgoing optical fiber 13, and then exported by the outgoing optical fiber 13 for detection.

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Abstract

The dissolving degree detector for on-line continuous detection of multiple component medicine has the structure comprising sample introducing system, optical path system, spectral detection system and computer system. The sample introducing system consists of sampling tube, creepage pump, six-channel flow pond, stepped motor, round bottom beaker, etc.; the optical path system on two sides of the six-channel flow pond consists of light source, incident grating and outgoing optical fiber; and the spectral detection system includes modular flattened field grating and ultraviolet reinforced linear CCD array detector. The present invention has the features of fast measurement speed, reduced measurement lagging, capability of multiple component dissolving degree detection, computer control and data processing, etc.

Description

technical field [0001] The invention belongs to an instrument capable of continuously and rapidly detecting the dissolution rate of multi-component medicines on-line. Background technique [0002] For a long time, among the instruments used in the field of drug dissolution testing, the drug solution was extracted manually from the dissolution apparatus, and after filtering, it was detected by a UV-visible spectrophotometer. This dissolution determination method has disadvantages such as time-consuming, laborious, measurement lag, and inconvenient operation. Due to many manual steps in the measurement process, it requires high professional knowledge, skills and proficiency of operators. In recent years, the commercialized drug dissolution apparatus has solved these problems to a certain extent, but there are generally problems that the degree of automation is not high and there are many manual operations. In addition, its cost is relatively high, so it is not completely suit...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N21/33G01N1/14G01N21/05
Inventor 金钦汉邹向宇曹彦波
Owner JILIN UNIV
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