Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Hydrolysable tannin and application thereof

A technology for hydrolyzing tannin and methanol, which is applied to medical preparations containing active ingredients, plant raw materials, esterified saccharides, etc., can solve the problem of not disclosing the use of such compounds and the like

Inactive Publication Date: 2010-05-19
SOUTHERN MEDICAL UNIVERSITY
View PDF1 Cites 2 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But the above-mentioned article does not disclose the purposes of this type of compound, also does not see other reports

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Hydrolysable tannin and application thereof
  • Hydrolysable tannin and application thereof
  • Hydrolysable tannin and application thereof

Examples

Experimental program
Comparison scheme
Effect test

preparation example

[0041] 1. Obtaining of the compound of the present invention

[0042] (1) Take the wild snake, chop it, soak it with 70% methanol or ethanol at room temperature for 24 hours, filter, remove the alcohol from the filtrate under reduced pressure, and obtain the total extract;

[0043] (2) The total extract is diluted with an appropriate amount of water, then extracted with ether and ethyl acetate successively, and the water-soluble part is taken;

[0044] (3) The water-soluble part is subjected to MCI-gel CHP20P column chromatography, and the sugar compound is washed away with water first, and then eluted with a gradient of 10% to 40% methanol, and the methanol eluate is collected;

[0045](4) The eluate obtained in step (3) is eluted with Chromatorex ODS with water and then with 10-80% methanol, collects 40-80% methanol eluate, recovers methanol under reduced pressure, and dissolves the residue with a little methanol ; Then apply MCI-gel CHP20P, elute with water and then 10-80%...

example 1

[0062] 【prescription】

[0063] Hydrolyzable Tannins 20g

[0064] Microcrystalline Cellulose 48g

[0065] Soluble starch 30g

[0066] Talc powder 2g

[0067] A total of 1000 tablets were produced, each containing 100 mg of the compound.

[0068] 【Preparation】

[0069] Weigh 20g of the compound, add soluble starch to dilute to 50g, mix well, then weigh 48g of microcrystalline cellulose, use 95% ethanol to make soft material, sieve and granulate, dry at low temperature at 50°C, granulate, add talc powder 2g , mixed evenly, compressed into tablets (0.1g each), inspected for quality, packaged, and obtained.

[0070] 【Dosage】

[0071] 3 tablets each time, 3 times a day.

[0072] 【For people】

[0073] Applicable to various tumor patients.

example 2

[0075] 【prescription】

[0076] Hydrolyzable Tannin 10g

[0077] Microcrystalline Cellulose 48g

[0078] Soluble starch 40g

[0079] Talc powder 2g

[0080] A total of 1000 tablets were produced, each containing 100 mg of the compound.

[0081] 【Preparation】

[0082] Weigh 10g of the compound, add soluble starch to dilute to 50g, mix well, then weigh 48g of microcrystalline cellulose, use 95% ethanol to make soft material, sieve and granulate, dry at low temperature at 50°C, granulate, add talc powder 2g , mixed evenly, compressed into tablets (0.1g each), inspected for quality, packaged, and obtained.

[0083] 【Dosage】

[0084] 3 tablets each time, 3 times a day.

[0085] 【For people】

[0086] Applicable to various tumor patients.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention provides a novel hydrolytic tannin of the pyran glucose category containing the coffee acyl. The chemical structure is as shown in formula (1); the compound of the invention can inhibitthe proliferation of tumor; the compound has the better anti-tumor activity and can be used to prepare the anti-tumor drugs.

Description

technical field [0001] The invention relates to the field of organic chemistry, in particular to caffeoyl-containing glucopyranose hydrolyzable tannins. Background technique [0002] Tannins, also known as vegetable tannins, are a class of complex polyphenolic compounds widely present in plants, among which hydrolyzable tannins are esters or glycosides formed of phenolic acids and polyols. [0003] In 2001, Zhi-hong Jiang and Yoko Hirose found a variety of glucopyranose hydrolyzable tannins containing caffeoyl and galloyl groups in snake mushroom (Balanophora japonica Makino), such as: 1-O-(E) -Caffeoyl-3-O-galloyl-β-D-glucopyranose, the compound is a yellow amorphous powder, [α] D 15 -48.9°(c=0.8, MeOH), can be hydrolyzed into gallic acid and 1-O-(E)-caffeoyl-β-D-glucopyranose under the action of tannase; 3-O-(E) -Caffeoyl-4-O-galloyl-D-glucopyranose, the compound is a yellow amorphous powder, [α] D 15 -144.2°(c=0.7, MeOH), under the action of tannase, it can be hydrol...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Patents(China)
IPC IPC(8): C07H13/10C07H9/02A61K31/7048A61K36/185A61P35/00
Inventor 姜志宏吴少瑜田中山中崇文晓芸刘中秋岩田弘美河野高畑勋吴曙光广濑小野
Owner SOUTHERN MEDICAL UNIVERSITY
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com