Method of reducing oral tissue inflammation using magnolia extract

A magnolia extract, a technique for tissue inflammation, which is applied to the treatment of mammalian subjects suffering from oral tissue inflammation in the oral cavity, the treatment of mammalian subjects suffering from oral tissue inflammation, the field of reducing oral tissue inflammation in mammalian subjects, and can solve the problem of depigmentation. , worsening tissue inflammation, exfoliative gingivitis, etc.

Inactive Publication Date: 2008-02-27
COLGATE PALMOLIVE CO
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

These treatments work to reduce the stimulus (bacteria) but cannot easily affect the host's immune response to the toxins secreted by the bacteria
In addition, certain antibiotics and other bacteriostatic therapies may lead to ulceration of the oral mucosa, causing exfoliative gingivitis, discoloration, potential antibiotic resistance after prolonged use, and exacerbation of tissue inflammation due to irritation

Method used

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  • Method of reducing oral tissue inflammation using magnolia extract
  • Method of reducing oral tissue inflammation using magnolia extract

Examples

Experimental program
Comparison scheme
Effect test

Embodiment I

[0093] Dentifrice compositions having the ingredients listed in Table I were prepared as follows. Magnolia extract obtained by HFA-13A separation has about 15% by weight of honokiol and 37% by weight of magnolol.

[0094] Disperse the sodium saccharin, sodium fluoride and any other salts in the water and stir to mix in a conventional mixer. A humectant such as glycerin and sorbitol is added to the water mixture with stirring. Organic thickeners, such as carrageenan and CMC, and any polymers are then added. The resulting mixture was stirred until a homogeneous colloidal phase formed. The mixture was then transferred to a high speed vacuum blender; the SYLODENT(R) XWA 650 and SYLODENT(R) 783 abrasives and the silica thickener ZEODENT(R) 165 were added to the blender. The mixture is then mixed at high speed for 5 to 30 minutes under a vacuum of about 20 to 50 mm Hg, preferably about 30 mm Hg. Weigh out the flavored oil, then blend the magnolia into the flavored oil. Blend th...

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Abstract

A method for treating a mammal having oral tissue inflammation is provided, where the inflamed oral tissue is contacted with a safe, efficacious, non-irritating oral composition having an anti-inflammatory agent comprising a magnolia extract. The magnolia anti-inflammatory active ingredient reduces one or more mediators of inflammation and reduces inflammation in oral tissue. The oral composition can be in the form of a mouth rinse; dentifrice, including toothpaste, gels, powders, lozenges; medicament gel; animal products; and the like.

Description

[0001] Related application introduction [0002] This application claims priority to US Provisional Patent Application Serial No. 60 / 640,161, filed December 29, 2004, the contents of which are incorporated herein by reference. Background of the invention [0003] Gingivitis is inflammation or infection of the gums and alveolar bone that support the teeth. Gingivitis is generally thought to be caused by bacteria in the mouth (particularly those responsible for plaque formation) and toxins formed by the bacteria as by-products. The toxin is thought to cause inflammation of the oral tissues in the mouth. Periodontitis, in contrast to gingivitis, is a progressive stage of the disease in which the gums become inflamed and begin to recede from the teeth and form periodontal pockets which can eventually lead to destruction of the bone and periodontal ligaments. Bacterial infections of structures supporting the dentition may include gingivitis and periodontitis, but may also include...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/57A61P29/00
Inventor A·加法D·谢尔S·M·赫尔斯
Owner COLGATE PALMOLIVE CO
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