Phenobarbitone chewable tablets for dog or cat
A technology of phenobarbital and chewable tablets, which is applied in the field of veterinary drug preparations, can solve problems such as poor palatability, and achieve the effect of reducing waste and improving the cure rate
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Embodiment 1
[0018] Embodiment 1: Phenobarbital Chewable Tablets
[0019] Take 2400g of starch and bake it at 100°C for 1 hour, cool to room temperature; take another 600g of phenobarbital and 60g of aspartame, dilute and mix with the cooled starch by equal amount incremental dilution method, pass through 60 meshes, and refine Mixture A was obtained by sieving three times. Put mixture A, 600 g of oral glucose, 600 g of skimmed milk powder and 174 g of starch into a mixer and mix evenly to obtain mixture B, which is set aside. After mixing glycerin and absolute ethanol in a ratio of 1:10, 2.5 L was taken, and 200 g of polyvinylpyrrolidone was added thereto to prepare a polyvinylpyrrolidone glycerol-ethanol mixed solution.
[0020] Add the polyvinylpyrrolidone glycerol-ethanol mixed solution to the mixture B under stirring, until all the addition is complete, and a soft material with uniform mixing and moderate humidity is obtained. Granulate with a 16-mesh sieve and ventilate and dry at 5...
Embodiment 2
[0029] Embodiment 2: Phenobarbital Chewable Tablets
[0030] Get starch 2100g, phenobarbital 1800g, aspartame 300g and prepare mixture A by the method described in Example 1.
[0031] Put mixture A, 900 g of oral glucose, 900 g of skimmed milk powder and 1500 g of starch into a mixer and mix evenly to obtain mixture B, which is set aside. Mix glycerin and absolute ethanol uniformly at a ratio of 1:5, take 2.5 L, add 200 g of polyvinylpyrrolidone to it to make a polyvinylpyrrolidone glycerol-ethanol mixed solution as a binder.
[0032] Add the polyvinylpyrrolidone glycerol-ethanol mixed solution to the mixture B under stirring, until all the addition is complete, and a soft material with uniform mixing and moderate humidity is obtained. Accurately weigh 30 g of magnesium stearate for granulation, granulate, dry, granulate, and compress according to the method described in Example 1. About 10,000 tablets were made, each weighing 0.6g, containing 0.18g of phenobarbital.
Embodiment 3
[0033] Embodiment 3: Phenobarbital Chewable Tablets
[0034] Get starch 1380g, phenobarbital 1200g, aspartame 180g, prepare mixture A by the method described in Example 1. Put mixture A, 750 g of oral glucose, 750 g of skimmed milk powder and 1620 g of starch into a mixer and mix evenly to obtain mixture B, which is set aside. Mix glycerin and absolute ethanol uniformly at a ratio of 1:10, take 2.5 L, add polyvinylpyrrolidone 200 g to it to make a polyvinylpyrrolidone glycerol-ethanol mixed solution as a binder.
[0035] Add the polyvinylpyrrolidone glycerol-ethanol mixed solution to the mixture B under stirring, until all the addition is complete, and a soft material with uniform mixing and moderate humidity is obtained. Accurately weigh 60 g of magnesium stearate for granulation, granulate, dry, granulate, and compress according to the method described in Example 1. A total of about 10,000 tablets were made, each weighing 0.6g, containing 0.12g of phenobarbital.
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