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Application of RAGE Gly82Ser mutant in preparing gastric cancer screening agent

A technology for mutants and gastric cancer, applied in biochemical equipment and methods, microbial measurement/inspection, etc., can solve problems such as the unseen RAGEGly82Ser gene mutation kit

Inactive Publication Date: 2010-06-09
NANJING MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

There is no report on the application of the RAGE Gly82Ser gene mutation kit in the screening of gastric cancer

Method used

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  • Application of RAGE Gly82Ser mutant in preparing gastric cancer screening agent
  • Application of RAGE Gly82Ser mutant in preparing gastric cancer screening agent
  • Application of RAGE Gly82Ser mutant in preparing gastric cancer screening agent

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Embodiment Construction

[0012] The present invention will be specifically described below.

[0013] 1. Materials and methods

[0014] (1) Subjects:

[0015] This is a case-control study, including 283 gastric cancer patients and 283 cancer-free controls. The study was approved by the Ethics Committee of the First Affiliated Hospital of Nanjing Medical University. Cases were newly admitted patients with histologically diagnosed gastric cancer, consecutively recruited from the Affiliated Hospital of Nanjing Medical University. Those cases with secondary, regenerative tumors were excluded. The control group was an admitted patient at the same period without any history of cancer or genetic disease. They were age (within 5 years old) and gender matched. All subjects were unrelated Han Chinese. Information on age, sex, smoking status, place of residence, weight, and personal medical history was collected through questionnaires [4-6]. Smokers were defined as those who had previously or recently smok...

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Abstract

The invention discloses an application of late glycosylated end-product receptor gene (RAGE) mutant Gly82Ser in preparing detection screening agent for gastric cancer risk group. The invention develops the application value of RAGE Gly82Ser mutant in the detection and screening gastric cancer risk group, arouses high alert of detected person and clinical doctors through detecting the mutant (Gly82Ser) in RAGE extron 3.

Description

technical field [0001] The invention belongs to the field of biotechnology, and in particular relates to a new application of a gene mutant. Background technique [0002] The occurrence of gastric cancer is a complex, multi-stage, multi-factor process [1,2]. Similar to many malignant tumors, gastric cancer is the result of the interaction of environmental factors and host genetic factors [3], and nearly 42% of gastric cancers in the world occur in China [1]. Our past epidemiological studies also provided evidence that the risk of gastric cancer was associated with gene mutations [4-6]. [0003] The receptor for advanced glycation end products (RAGE) is a member of the immunoglobulin superfamily [7]. It is involved in many important pathologies including Alzheimer's disease, diabetes, inflammation and cancer [8-11]. RAGE stimulates cancer growth, survival and metastasis [11]. In addition, RAGE expression is closely related to gastric cancer invasion and metastasis [12]. ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C12Q1/68
Inventor 王斌杨力顾海娟孙庆敏丛日红曾樱汤纳平周波
Owner NANJING MEDICAL UNIV
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