New purpose of total steroidal saponin extract

A technology of total saponins and extracts, which is applied in the field of traditional Chinese medicine and can solve problems such as the new use of steroidal total saponins extracts for cardiac neurosis.

Active Publication Date: 2008-08-20
CHENGDU DIAO PHARMA GROUP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, no new application of steroidal total saponins ex...

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  • New purpose of total steroidal saponin extract
  • New purpose of total steroidal saponin extract

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] Preparation and assay of embodiment 1 steroidal total saponins extract

[0019] Weigh 100kg of the dried rhizome of Dioscorea chinensis, crush it, add 800ml of 75% ethanol to reflux and extract for 3 times, the first time is 3 hours, the second time and the third time are 2 hours each, filter, combine the extracts, recover the ethanol, add water to 2g / ml, refrigerated for 24 hours, centrifuged, supernatant over HPD 300 The macroporous adsorption resin column is first washed with water until the effluent is colorless, then eluted with 70% ethanol, the ethanol eluate is collected, the ethanol is recovered, concentrated to an extract, and vacuum-dried to obtain the total steroidal saponin extract. Take about 0.3g of this product, weigh it accurately, put it in a 150ml round bottom flask, add 50ml of sulfuric acid 40% ethanol solution, put it in a boiling water bath and reflux for 5 hours, let it cool, add 100ml of water, shake well, and dry at 105°C to constant weight No...

Embodiment 2

[0020] Preparation and assay of embodiment 2 steroidal total saponins extract

[0021] Weigh 100kg of the dried rhizome of the traditional Chinese medicine yellow yam, crush it, add 1200ml of 95% ethanol to reflux and extract 3 times, the first time for 3 hours, the second and third times for 2 hours each, filter, combine the extracts, recover the ethanol, add water to 2g / ml, refrigerated for 24 hours, centrifuged, and the supernatant was passed through a macroporous adsorption resin column (HPD 100 / LD140=7:3 (W / W)), wash with water until the effluent is colorless, then elute with 70% ethanol, collect the ethanol eluate, recover ethanol, concentrate to extract, and vacuum dry to obtain Steroidal Total Saponin Extract. Calculated with reference to the detection method of Example 3, this product is calculated as a dry product, and the total steroidal saponins contained in the total steroidal aglycone are 70%.

[0022] Prove the beneficial effect of the present invention belo...

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Abstract

The invention provides a new use of steroid total saponins extract, in particular to a use of preparation for curing heart neurosis drugs. The invention also provides a drug composition for curing heart neurosis. The inventor finds that the steroid total saponins extract has obvious function of curing heart neurosis, improving patient clinical symptoms through experimental studies. The new use has the advantages of ability to provide a new, outstanding therapeutic effect drug selection, and good economic and social benefits.

Description

technical field [0001] The invention relates to a new pharmaceutical application of steroidal total saponins extract, specifically the use of steroidal total saponins extract in preparing medicines for treating cardiac neurosis, and belongs to the technical field of traditional Chinese medicines. Background technique [0002] Cardiac neurosis, once called cardiovascular neurosis, cardiac neurosis, functional heart discomfort, etc., is a special type of neurosis. The subjective symptoms are mainly cardiovascular system dysfunction, combined with psychological obstacles. Most of them occur in young people and middle-aged people, and the most common cases are those aged 20-40. There are more women than men, especially menopausal women, and the main complaints are multiple and scattered, such as palpitations, dyspnea, and precordial pain (but the location is often not fixed, and it can last for several seconds or hours; the onset of pain has nothing to do with activities , most...

Claims

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Application Information

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IPC IPC(8): A61K31/56A61K36/894A61P25/02
Inventor 李伯刚邹文俊白红艳黄坤石金发刘忠荣王若竹
Owner CHENGDU DIAO PHARMA GROUP
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