Non-steroid progestogen receptor regulator, preparation thereof, pharmaceutical compositions and uses

A compound and pharmaceutical technology, applied in the field of medicinal chemistry, can solve the problems of poor prognosis of breast cancer and reduce the adhesion of breast cancer cells

Inactive Publication Date: 2008-10-22
SHANGHAI INST OF MATERIA MEDICA CHINESE ACAD OF SCI +1
View PDF9 Cites 5 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

If overexpression of hPR-A in T47D cell line can reduce the adhesion of breast cancer cells an

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Non-steroid progestogen receptor regulator, preparation thereof, pharmaceutical compositions and uses
  • Non-steroid progestogen receptor regulator, preparation thereof, pharmaceutical compositions and uses
  • Non-steroid progestogen receptor regulator, preparation thereof, pharmaceutical compositions and uses

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

Embodiment 2

Embodiment 3

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

PropertyMeasurementUnit
Melting pointaaaaaaaaaa
Melting pointaaaaaaaaaa
Melting pointaaaaaaaaaa
Login to view more

Abstract

The invention relates to a modulator of nonsteroidal progesterone receptor with a structure of the general formula I or an acceptable salt on pharmacy and a preparation method thereof. The invention also relates to drug combination including compounds of the general formula I or an acceptable salt on pharmacy thereof and the antagonist activity of progesterone receptor which is provided by the compounds of the general formula I or the acceptable salt on pharmacy thereof; therefore, the invention can be used for preparing nonsteroidal drugs to prevent and (or) or treat symptoms or diseases such as secondary amenorrhea, functional bleeding disorder, uterine fibroids, endometriosis, polycystic ovary syndrome, breast cancer, contraceptive, induced labor, and termination of pregnancy, etc.

Description

Non-steroidal progesterone receptor modulator and its preparation method, pharmaceutical composition and use technical field The invention belongs to the field of medicinal chemistry, and relates to a non-steroidal progesterone receptor modulator, a preparation method thereof, a pharmaceutical composition and the preparation method for stopping early and mid-term pregnancy, emergency contraception, preventing and / or treating uterine fibroids and endometrium Use in medicine for symptoms or diseases such as atopy and breast cancer. Background technique Nuclear receptors (NR) form a class of structurally related regulators of gene expression called "ligand-dependent transcription factors" (R.M. Evans, Science, 240, 889, 1988). Steroid hormone receptors are members of the nuclear receptor family that includes the progesterone receptor (PR), estrogen receptor (ER), androgen receptor (AR), glucocorticoid receptor (GR), and mineralocorticoid Hormone receptors (MRs). For the pr...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
IPC IPC(8): C07C225/22C07C225/04C07D333/20C07D295/04A61K31/136A61K31/381A61K31/535A61P5/36
Inventor 沈竞康王明伟杜永丽冯杨李群益
Owner SHANGHAI INST OF MATERIA MEDICA CHINESE ACAD OF SCI
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap