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Non-steroid progestogen receptor regulator, preparation thereof, pharmaceutical compositions and uses

A compound and pharmaceutical technology, applied in the field of medicinal chemistry, can solve the problems of poor prognosis of breast cancer and reduce the adhesion of breast cancer cells

Inactive Publication Date: 2008-10-22
SHANGHAI INST OF MATERIA MEDICA CHINESE ACAD OF SCI +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

If overexpression of hPR-A in T47D cell line can reduce the adhesion of breast cancer cells and inhibit the effect of progesterone, it may be related to the poor prognosis of breast cancer

Method used

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  • Non-steroid progestogen receptor regulator, preparation thereof, pharmaceutical compositions and uses
  • Non-steroid progestogen receptor regulator, preparation thereof, pharmaceutical compositions and uses
  • Non-steroid progestogen receptor regulator, preparation thereof, pharmaceutical compositions and uses

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Abstract

The invention relates to a modulator of nonsteroidal progesterone receptor with a structure of the general formula I or an acceptable salt on pharmacy and a preparation method thereof. The invention also relates to drug combination including compounds of the general formula I or an acceptable salt on pharmacy thereof and the antagonist activity of progesterone receptor which is provided by the compounds of the general formula I or the acceptable salt on pharmacy thereof; therefore, the invention can be used for preparing nonsteroidal drugs to prevent and (or) or treat symptoms or diseases such as secondary amenorrhea, functional bleeding disorder, uterine fibroids, endometriosis, polycystic ovary syndrome, breast cancer, contraceptive, induced labor, and termination of pregnancy, etc.

Description

Non-steroidal progesterone receptor modulator and its preparation method, pharmaceutical composition and use technical field The invention belongs to the field of medicinal chemistry, and relates to a non-steroidal progesterone receptor modulator, a preparation method thereof, a pharmaceutical composition and the preparation method for stopping early and mid-term pregnancy, emergency contraception, preventing and / or treating uterine fibroids and endometrium Use in medicine for symptoms or diseases such as atopy and breast cancer. Background technique Nuclear receptors (NR) form a class of structurally related regulators of gene expression called "ligand-dependent transcription factors" (R.M. Evans, Science, 240, 889, 1988). Steroid hormone receptors are members of the nuclear receptor family that includes the progesterone receptor (PR), estrogen receptor (ER), androgen receptor (AR), glucocorticoid receptor (GR), and mineralocorticoid Hormone receptors (MRs). For the pr...

Claims

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Application Information

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IPC IPC(8): C07C225/22C07C225/04C07D333/20C07D295/04A61K31/136A61K31/381A61K31/535A61P5/36
Inventor 沈竞康王明伟杜永丽冯杨李群益
Owner SHANGHAI INST OF MATERIA MEDICA CHINESE ACAD OF SCI
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