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Application of tetrahydrocurcumin in preparing antidepressant and method for preparing solid dispersion of tetrahydrocurcumin

A technology of tetrahydrocurcumin and solid dispersion, which is applied in food preparation, pharmaceutical formulations, medical preparations of non-active ingredients, etc.

Inactive Publication Date: 2009-09-30
FUJIAN MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, whether tetrahydrocurcumin has antidepressant effect has not been reported in the literature at home and abroad.

Method used

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  • Application of tetrahydrocurcumin in preparing antidepressant and method for preparing solid dispersion of tetrahydrocurcumin
  • Application of tetrahydrocurcumin in preparing antidepressant and method for preparing solid dispersion of tetrahydrocurcumin
  • Application of tetrahydrocurcumin in preparing antidepressant and method for preparing solid dispersion of tetrahydrocurcumin

Examples

Experimental program
Comparison scheme
Effect test

example 1

[0021] Example 1 Mice forced swimming test

[0022] Male Kunming rats with a body weight of 18-22 g were selected, and put into a water tank (25 cm high, 18 cm in diameter) with a water depth of 10 cm 1 hour after administration, and the water temperature was 25°C. Observe for 6 minutes, and compare the difference in immobility time in the last 4 minutes between the control group and the treatment group. Two to three days before the experiment, the mice were given double-distilled water, and the same conditions were used for preliminary screening, and the mice whose immobility time was 70-160 seconds within 4 minutes after the selection were selected for the formal experiment.

[0023] The 60 qualified mice screened were randomly divided into 6 groups with 10 mice in each group. One hour before the experiment, the control group was given excipients of the same volume and concentration as the control group, the fluoxetine positive control group was given fluoxetine 80.00 mg / kg...

example 2

[0030] Example 2 Mouse tail suspension test

[0031] Select male Kunming rats with a body weight of 18-22 g, and 1 hour after the administration, stick the 2 cm of the tail end on a horizontal glass rod, so that the mouse is in an upside-down state, and its head is about 5 cm away from the table. Plates separate the mice from sight. Observe for 6 minutes, and compare the immobility time of the administration group and the control group within the last 5 minutes. Two to three days before the experiment, the mice were given double-distilled water and the same conditions were used for preliminary screening, and the mice whose immobility time was 70-160 seconds within 5 minutes after the selection were selected for the formal experiment. The grouping and administration of this experiment were the same as the forced swimming experiment of mice. The experimental results are shown in Table 3 and Table 4.

[0032] Table 3 Effect of single administration of tetrahydrocurcumin on the...

example 3

[0037] Example 3 5-HTP induced mouse head shake experiment

[0038] Sixty male Kunming mice weighing 18-22 g were randomly divided into 6 groups, 10 in each group. The experimental administration was the same as the forced swimming test of mice administered continuously for 14 days. One hour after the last intragastric administration, the mice were intraperitoneally injected with 5-HTP70mg / kg, observed 10 minutes later, recorded the number of head shakes of the mice within 6 minutes, and compared the difference in the number of head shakes between the administration group and the control group. The experimental results are shown in Table 5.

[0039] Table 5 Effects of tetrahydrocurcumin on 5-HTP-induced head-shaking experiments in mice

[0040]

[0041]Table 5 shows that within a certain dose range, the intensity of action of tetrahydrocurcumin is dose-dependent, and after 14 days of continuous administration of tetrahydrocurcumin 5mg / kg, it can significantly enhance the ...

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Abstract

The invention relates to application of tetrahydrocurcumin in preparing an antidepressant and a method for preparing a solid dispersion of the tetrahydrocurcumin. The invention aims to provide the application of the tetrahydrocurcumin to prepare the antidepressant. The tetrahydrocurcumin and a surfactant are mixed in certain proportion to obtain the solid dispersion of the tetrahydrocurcumin. The method for preparing the solid dispersion of the tetrahydrocurcumin comprises the following steps that: according to the weight ratio of 1:3-1:30, the tetrahydrocurcumin and the surfactant are heated until completely melted, frozen in a low-temperature environment, and taken out, dried and crushed to obtain the solid dispersion of the tetrahydrocurcumin. The tetrahydrocurcumin and the solid dispersion of the tetrahydrocurcumin are used for preparing drugs, health care products, foods or food additives of relieving mental depression. The tetrahydrocurcumin has the function of relieving mental depression, and the function of the tetrahydrocurcumin is possibly related with the influence on a monoamine neurotransmitter system; moreover, compared with fluoxetine, the tetrahydrocurcumin has the advantages of low toxicity and good curing effect.

Description

technical field [0001] The invention relates to the use of tetrahydrocurcumin for preparing antidepressants and a preparation method of tetrahydrocurcumin solid dispersion. Background technique [0002] Tetrahydrocurcumin (THC, as shown in the figure below) is one of the main metabolites of curcumin, and its water solubility and stability are better than curcumin. At present, it is mainly used as an additive in cosmetic whitening agents, anti-aging health care products and weight loss drugs. [0003] [0004] According to foreign literature reports, both tetrahydrocurcumin and curcumin have antioxidant activity, but their pharmacological effects are different. [0005] Sandur et al. found that tetrahydrocurcumin has no inhibitory effect on TNF-induced NF-kappaB activation, its anti-inflammatory effect is weaker than curcumin, and its inhibitory effect on cell growth is much weaker than curcumin. [0006] The study by Pari et al. showed that in diabetic rats treated with...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/12A61K9/14A61K47/34A23L1/30A61P25/24A23L33/10A61K47/10A61K47/26
Inventor 许建华魏小娟黄秀旺温彩霞
Owner FUJIAN MEDICAL UNIV
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