Fluidic cell manipulator

A manipulator and flow generator technology, applied in the field of particles, can solve the problems of false detection, hindered detection, etc., and achieve the effect of small change and/or damage
CN101548172AInactive Publication Date: 2009-09-30KONINKLIJKE PHILIPS ELECTRONICS NV
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
KONINKLIJKE PHILIPS ELECTRONICS NV
Publication Date
2009-09-30
Estimated Expiration
Not applicable · inactive patent

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Abstract

The present invention discloses a system (100) for individually manipulating, e.g. orienting, a particle (104) in a fluid (106). The manipulating system (100) comprises a particle trapping system (111) allowing trapping of the particle (111) in a fluid channel (102) and a controller for controlling shear force gradients on the particle. Shear force gradients on the particle are 5 controlled by positioning a particle off center in the fluid channel (102) in a laminar flow or by controlling the laminar flow itself. The laminar flow thereby is generated using a flow generator (108). The system (100) for manipulating may be used in a particle characterization system or may be used for performing actions on the particle (104) under predetermined orientations.
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Description

technical field

[0001] The present invention relates to the field of particle characterization and manipulation. More specifically, the invention relates to methods and systems for manipulating objects or particles, such as biological cells, to examine or characterize them, and to software for implementing such methods. Background technique

[0002] Analyte characterization is often used in chemical, biochemical or biological assays to detect the presence of certain types of analytes. For example, by detecting and / or characterizing cellular properties, malignant cells, such as precancerous cells, can in principle be detected, thereby offering the possibility to detect and / or monitor disease progression, such as progression from pre-invasive to invasive. Detection and / or characterization of individual particles, as commonly used in biosensor applications, allows qualitative and quantitative results to be obtained. One option for detecting the properties of individual partic...

Claims

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