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Difunctional imaging agent for SPECT and MRI and preparation method thereof

An imaging agent and dual-function technology, applied in the field of dual-function imaging agents, can solve problems such as long inspection time and increased risk of drug side effects, and achieve the effects of reducing injection times, saving inspection time, and improving image quality

Inactive Publication Date: 2009-10-14
THE AFFILIATED HOSPITAL OF SOUTHWEST MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Due to the different principles of nuclear medicine imaging and magnetic resonance imaging, the imaging agents or contrast agents used are different. When patients undergo these two examinations, they need to inject different drugs respectively, which will take a long time for the examination and require Injecting larger doses of the drug increases the risk of side effects from the drug

Method used

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  • Difunctional imaging agent for SPECT and MRI and preparation method thereof
  • Difunctional imaging agent for SPECT and MRI and preparation method thereof
  • Difunctional imaging agent for SPECT and MRI and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 199m

[0034] Example 1 99m Tc-Gd-DTPA imaging agent

[0035] In this embodiment 99m Tc-Gd-DTPA imaging agent is prepared by the following method:

[0036] Weigh 10mg of Gd-DTPA into a closed reaction vessel, add SnCl 2 1.0mg, adjust the pH value of the reaction system to 4.0. Fill the airtight reaction container with liquid nitrogen for cooling and drying, and prepare the above reactant into a freeze-dried kit. Add freshly rinsed Na to the lyophilized kit 99m TCO 4 Solution 37-1850MBq (0.5-2mL), mix well, react in 20℃-45℃ water bath for 20-45 minutes, the obtained solution is 99m Tc-Gd-DTPA dual function imaging agent.

[0037] Determined by TLC 99m Labeling rate of Tc-Gd-DTPA imaging agent in developing agent 0.9% saline 99m The Rf of Tc-Gd-DTPA is 0.9-1.0, and the Rf in acetone is 0-0.1. calculate 99m The labeling rate of Tc-Gd-DTPA was 98.7%. Within 6 hours at room temperature, the labeling rate was 96%.

Embodiment 299m

[0038] Example 2 99m Tc-Gd-DTPA-diglumine imaging agent

[0039] 99m Preparation of Tc-Gd-DTPA-digglumine marker: Weigh 10 mg of Gd-DTPA-digglumine, add SnF 2 1.0 mg, adjust the pH value of the reaction system to 2.0, fill with nitrogen, cool and dry, and prepare a freeze-dried kit. Add freshly rinsed Na to the lyophilized kit 99m TCO 4 Solution 37-1850MBq (0.5-2mL), mix well, react in a water bath at room temperature for 30-45 minutes, the resulting solution is 99m Tc-Gd-DTPA-diglumine bifunctional imaging agent. Determination of its labeling rate by TLC, in developing agent 0.9% normal saline 99m Rf in Tc-Gd-DTPA-diglumine is 0.9-1.0, and Rf in acetone is 0-0.1. calculate 99m The labeling rate of Tc-Gd-DTPA-diglumine was 98.0%. Within 6 hours at room temperature, the labeling rate was 95.6%.

Embodiment 399m

[0040] Example 3 99m Tc-Gd-BOPTA Imaging Agent

[0041] 99m Preparation of Tc-Gd-BOPTA marker: Weigh 10 mg of Gd-BOPTA, add 1.0 mg of stannous citrate, adjust the pH of the reaction system to 3.0, fill with nitrogen, cool and dry, and prepare a lyophilized kit. Add fresh rinse Na to the lyophilized kit 99m TCO 4 Solution 37-1850MBq (0.5-2ml), mix thoroughly, and react in a water bath at room temperature -45°C for 20-45 minutes. The labeling rate was determined by TLC, 99m Tc-Gd-BOPTA labeling rate is greater than 98.0%.

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Abstract

The invention discloses a difunctional imaging agent which is applicable to SPECT and MRI. The difunctional imaging agent which is provided by the invention and used for the SPECT and MRI is a compound which is formed by the combination of Tc and magnetic resonance contrast agent. The difunctional imaging agent has the advantages of high sensitivity, high spatial resolution, high accuracy and simple marking, can simultaneously achieve the detection of two kinds of imaging equipment, reduces the injection times, decreases the dosage and saves the check time.

Description

technical field [0001] The invention relates to a medical image imaging agent, in particular to a dual-function imaging agent suitable for SPECT and MRI. Background technique [0002] Nuclear medicine imaging is an imaging technique that detects radiopharmaceuticals that have entered the body. Nuclear medicine imaging equipment mainly includes single photon emission computed tomography (Single Photon Emission Computed Tomography, SPECT) and positron emission computed tomography (Positron Emission Tomography, PET). The principle of nuclear medicine imaging: the radiopharmaceuticals used for imaging are concentrated in specific tissues and organs in the body. Obtain images of organs or lesions in vitro. [0003] The imaging agents used for different organ functions are often different. Among the many radionuclides, the radionuclide technetium[ 99m Tc] has ideal nuclear physical properties, its half-life is 6.02h, and it emits 140keV γ-rays. It is an irreplaceable nuclide fo...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K51/04A61K49/06A61K103/34
Inventor 陈跃黄占文丁志凌张伟蔡亮曹丰
Owner THE AFFILIATED HOSPITAL OF SOUTHWEST MEDICAL UNIV
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