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Glycerol fructose liposome drug combination injection and preparation method thereof

A technology of injection and glycerin, applied in the field of medicine, can solve problems such as poor stability, achieve the effects of stable product quality, improve therapeutic index, and reduce drug side effects

Inactive Publication Date: 2010-01-27
灵康药业集团股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] Aiming at the poor stability of the current glycerol fructose injection, the object of the present invention is to provide a stable glycerol fructose injection, specifically, the present invention relates to a glycerol fructose lipos

Method used

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  • Glycerol fructose liposome drug combination injection and preparation method thereof
  • Glycerol fructose liposome drug combination injection and preparation method thereof
  • Glycerol fructose liposome drug combination injection and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] Example 1 Preparation of Glycerol Fructose Liposomes

[0029] Prescription: Glycerin 25g

[0030] Fructose 12.5g

[0031] Egg yolk lecithin 250g

[0032] Cholesterol 20g

[0033] Sodium deoxycholate 15g

[0034] Vitamin E 30g

[0035] Sodium chloride 2.25g

[0036] Preparation Process

[0037] (1) 250g egg yolk lecithin, 20g cholesterol, 15g sodium deoxycholate and 30g vitamin E are dissolved in 500ml of n-hexane;

[0038] (2) 25g of glycerin, 12.5g of fructose and 2.25g of sodium chloride are dissolved in 200ml of water;

[0039] (3) the two are mixed and stirred to form a W / O type emulsion, heated and stirred to evaporate, and when the mixture reaches a viscous state, add 50ml of pH value 4.5 acetic acid-sodium acetate buffer solution, continue to heat and stir to evaporate to remove residual n-hexane, Sonicate for 30 minutes, transfer to a high-speed homogeneous mixer, stir and homogenize for 30 minutes to obtain glycero...

Embodiment 2

[0052] Example 2 Preparation of Glycerol Fructose Liposomes

[0053] Prescription: Glycerin 50g

[0054] Fructose 25g

[0055] Soy Phosphatidylinositol 200g

[0056] Cholesterol 50g

[0057] Sodium deoxycholate 25g

[0058] tert-Butyl p-Hydroxyanisole 40g

[0059] Sodium chloride 4.5g

[0060] Preparation Process

[0061] (1) 200g soybean phosphatidylinositol, 50g cholesterol, 25g sodium deoxycholate and 40g tert-butyl p-hydroxyanisole are dissolved in 500ml of n-butanol;

[0062] (2) 50g of glycerin, 25g of fructose and 4.5g of sodium chloride are dissolved in 200ml of water;

[0063] (3) Mix the two and stir to form a W / O emulsion, heat and stir to evaporate, when the mixture reaches a viscous state, add 50ml of sodium dihydrogen phosphate-disodium hydrogen phosphate buffer solution with a pH value of 5.0, continue to heat and stir to evaporate Remove residual n-hexane, sonicate for 30 minutes, transfer to a h...

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PUM

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Abstract

The invention provides a glycerol fructose liposome drug combination injection and a preparation method thereof. The glycerol fructose liposome drug combination injection is characterized by comprising the following components by weight portion: 2 portions of glycerol, 1 portion of fructose, 5-20 portions of phospholipid, 1.5-2 portions of cholesterol, 1-1.5 potions of sodium deoxycholate and 0.1-0.5 potion of sodium chloride. The glycerol fructose liposome injection is prepared through reverse phase evaporation according to the proportion of specific auxiliary materials to raw auxiliary materials, is stable, solves the problems of poor stability and large fluctuation of pH value in the prior art, and is more suitable for clinical application.

Description

technical field [0001] The invention relates to a liposome preparation, in particular to a glycerol-fructose liposome pharmaceutical composition injection and a preparation method, and belongs to the technical field of medicine. Background technique [0002] Glycerin Fructose Injection is a hyperosmotic preparation. Through hyperosmotic dehydration, it can reduce the water content of the brain, eliminate cerebral edema, reduce intracranial pressure, make the patient wake up early in coma, and reduce disability. It can enter through the blood-brain barrier. Brain tissue, oxidized into phosphorylated matrix, is the only source of heat in brain tissue, can improve cerebral circulation, increase cerebral blood flow, increase cerebral oxygen consumption, and is used for head trauma, cerebral thrombosis, intracranial hemorrhage and other diseases. [0003] Intracranial hypertension is the most common disease in neurosurgery. Mannitol has been used for clinical treatment for a long...

Claims

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Application Information

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IPC IPC(8): A61K31/7004A61K31/047A61K9/127A61K47/24A61K47/28A61P7/10A61P43/00
Inventor 陶灵刚
Owner 灵康药业集团股份有限公司
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