Use of total flavonoids of Chrysanthemum in preparation of medicaments for preventing and curing myocardial hypertrophy and remodeling ventricle

A technique for myocardial hypertrophy and ventricular remodeling, applied in the field of medicine, can solve problems such as improving ventricular remodeling and myocardial hypertrophy

Inactive Publication Date: 2010-06-09
SHANGHAI UNIV OF T C M
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

So far, there is no report that the total flavonoids of wild chrys

Method used

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  • Use of total flavonoids of Chrysanthemum in preparation of medicaments for preventing and curing myocardial hypertrophy and remodeling ventricle
  • Use of total flavonoids of Chrysanthemum in preparation of medicaments for preventing and curing myocardial hypertrophy and remodeling ventricle
  • Use of total flavonoids of Chrysanthemum in preparation of medicaments for preventing and curing myocardial hypertrophy and remodeling ventricle

Examples

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[0077] Example 1 (Preparation of total flavonoids from wild chrysanthemum)

[0078] The wild chrysanthemum was refluxed with 70% ethanol (1:10 ratio) at 80°C for 2h. The filtrate was concentrated and extracted with petroleum ether for 5-7 times. Then the extract was concentrated and combined with the aqueous layer to obtain the extract. Dissolve the extract with distilled water and load the D101 macropore. The resin column is washed with distilled water and eluted with 70% ethanol. The eluate is collected and evaporated, concentrated and dried to obtain the total flavonoids of chrysanthemum. The purity of total flavonoids obtained by this method is between 50-80%.

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Abstract

The invention belongs to the technical field of medicines and particularly relates to the use of the total flavonoids of Chrysanthemum in the preparation of medicaments for preventing and curing myocardial hypertrophy and remodeling the ventricle. The total flavonoids of Chrysanthemum can reduce the myocardial hypertrophy index and myocardium AngII content of mice and reduce the myocardial hypertrophy index, blood pressure, neuroendocrine factor and myocardium Hyp content of pressure overloaded rats, reduce the section sea of the myocardial cells of the left ventricle of the pressure overloaded rats, reduce the myocardial collagen deposition and regulate the abnormal expression of myocardial MMP-2 and MMP-9 proteins and mRNA.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to the application of total flavonoids of wild chrysanthemum in the preparation of medicines for preventing and treating myocardial hypertrophy and ventricular remodeling. Background technique [0002] Chronic congestive heart failure (CHF) is a severe and common clinical syndrome, which is the terminal stage of many cardiovascular diseases. With the change of people's living standards and lifestyles, the intensification of competition, and the aging of society, the number of patients with heart failure, which is the terminal stage of all heart diseases, tends to increase. In heart failure, the research and prevention of ventricular remodeling are becoming more and more important and urgent. [0003] In the past, it was generally believed that myocardial hypertrophy and ventricular remodeling (ventricular remodeling, VR) were an initial compensatory response to increas...

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Application Information

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IPC IPC(8): A61K36/28A61P9/00A61P9/12A61P9/04A61K133/00
Inventor 吴琦陈长勋顾伟梁
Owner SHANGHAI UNIV OF T C M
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