Quality detecting method for indigowoad root heat removing pellet

A quality detection method, the technology of indigo, applied in the direction of measuring devices, pharmaceutical formulas, medical preparations containing active ingredients, etc., can solve the problems of poor indigo stability, low indigo content, poor quality control significance, etc., to achieve high quality Standard level, stable effect

Active Publication Date: 2011-07-20
KUNMING CHINESE MEDICINE FACTORY
View PDF0 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In the quality control standard [WS-10001(ZD-0001)-2005] of Banlan Qingre Granules promulgated by the State Food and Drug Administration, the content determination index is indigo, which is a fat-soluble component and has a low extraction transfer rate in water , there is a report in the literature: "Someone measured the content of indigo and indirubin in the water extract, and found that the extraction rate was only 1.5% to 3.5%. In addition, the loss rate during the concentration process was as high as 92.4%"
In the preparation process of Banlan Qingre Granules, the root system of Nanbanlan is decocted and extracted with water, so the content of indigo in the finished product is very low, only 0.3-0.6% per million, and the stability of indigo is poor. poor quality control

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0018] Banlanqingre granule drug formula: take 1500g of Nanlan root, 1g of menthol, 570g of sucrose, 380g or 450g of dextrin, and 4g of aspartame.

[0019] Preparation method: take Southern Radix Radix, add water and decoct twice, each time for 1.5 hours, combine the decoction, filter, and concentrate the filtrate to a thick paste with a relative density of 1.36-1.38 (60°C), take the thick paste, add sucrose powder, Dextrin and menthol (add after dissolving with appropriate amount of ethanol), make granules, dry at low temperature, and make 1000g; or take thick paste, add dextrin, aspartame and menthol (add after dissolving with appropriate amount of ethanol), Make granules, dry at low temperature, and make 500g (sugar-free type).

[0020] Properties: This product is gray-brown to dark-brown granules, pungent, cool, sweet, slightly bitter; or light brown to tan granules, bitter, pungent, slightly sweet (sugar-free type).

[0021] 1. Take 2 bags of Banlan Qingre Granules (here...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
wavelengthaaaaaaaaaa
Login to View More

Abstract

The invention relates to a quality detecting method for a medicament indigowoad root heat removing pellet [WS-10001(ZD-0001)-2005] approved by a state food and drug administration of the People's Republic of China. The method comprises a thin-layer chromatography identifying method of indirubin, a thin-layer chromatography identifying method of menthol, a detecting method of an ethanol extract and a content detecting method of adenosine. In the quality detecting method for the indigowoad root heat removing pellet, the thin-layer chromatography qualitative identifying method of menthol is improved, and the limitation of the ethanol extract is revised so that the product quality can be more reasonably controlled; and the content test detecting method of adenosine in a preparation is established. The adenosine is a water-soluble component, has the inflammatory resisting effect and stable property and is one of effective components of rhizoma et radix baphicacanthis cusiae; the adenosine selected as a content detecting index can more accurately control the quality of a finished product; and the improvement of the quality control method for the indigowoad root heat removing pellet ensures the higher quality standard level of a complex preparation.

Description

technical field [0001] The invention relates to a quality detection method for Banlan Qingre Granules [WS-10001(ZD-0001)-2005] approved by the State Food and Drug Administration of the People's Republic of China. technical background [0002] Banlan Qingre Granules, a drug approved by the State Food and Drug Administration of the People's Republic of China, have the functions of clearing heat, detoxifying, dispelling wind-heat, relieving throat and reducing swelling. The compound preparation is composed of 1500g of the traditional Chinese medicine Radix isatidis and 1g of menthol, and the above-mentioned raw materials are made into 1000g or 500g (sugar-free type). Nanbanlangen is the dry rhizome and root of Baphicacanthus cusia (Nees) Bremek., a plant of the family Acanthaceae. It has the effects of clearing heat, detoxifying, and cooling blood; menthol is a saturated cyclic alcohol obtained from mint oil, which belongs to aromatic medicine. , flavoring medicine and carmina...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & AuthorityPatents(China)
IPC IPC(8): G01N30/90G01N30/02A61K36/534A61P11/04A61P31/12
Inventor孙蓉朱敏
OwnerKUNMING CHINESE MEDICINE FACTORY