Ligustrazine nanoparticle, preparation method and pharmaceutical application thereof

Abstract

The invention relates to a ligustrazine nanoparticle, a preparation method and pharmaceutical application thereof. The preparation method comprises the following steps of: dissolving polylactic acid in acetone to form a polylactic acid acetone solution; then dissolving ligustrazine in the polylactic acid acetone solution to form an oil phase; adding the oil phase to a surface active agent-contained aqueous phase solution which is at the constant temperature of 20-50 DEG C; after the two phases are mixed, stirring for 50-90min at the temperature of 20-50 DEG C to make acetone volatilize to obtain a ligustrazine nanoparticle solution. The invention has simple process, mild reaction condition, even manufactured particle size and narrow distribution. Moreover, adopted auxiliary materials are biodegradable and have good biocompatibility, no toxic or side effects and sufficient market raw materials. Wrapped in the nanoparticle, ligustrazine can stably and slowly release, can effectively prevent and treat postoperative adhesion intestine and prevent postoperative adhesive intestinal obstruction.

Description

1. Technical field [0001] The invention belongs to the technical field of medicine, and specifically relates to a ligustrazine nanoparticle, a preparation method thereof, and an application in the field of pharmacy. 2. Background technology [0002] Abdominal adhesion is an inevitable process of postoperative peritoneal repair. After abdominal surgery, fibrinogen colloid will ooze from the local wound, which will quickly transform into fibrin coagulation, covering the wounded peritoneal surface, and repairing and protecting the wound. There is no repair without adhesions, but when the body's repair is disordered or the fiber degradation is incomplete so that it develops into punctate, angled or cord-like adhesions, it may lead to mechanical intestinal obstruction in patients. Adhesive ileus has been reported in more than 40% of patients after abdominal surgery. [0003] For the prevention of adhesive intestinal obstruction, at present, the improvement of surgical technique...

AI Technical Summary

Problems solved by technology

[0003] For the prevention of adhesive intestinal obstruction, at present, the improvement of surgical techniques, the use of barrier substances and the combination of drugs are mainly used to reduce fibrin deposition, promote fibrinolysis, and reduce excessive adhesions. However, due to the uncertainty of surgical techniques and the current There are disadvantages such as unstable efficacy of therapeutic drugs, inconvenient continuous administration, and poor effect of simple mechanical isolation.

Therefore, this common pathological abdominal adhesion, which has no effective prevention and treatment measures so far, has always been an important topic in the anti-tissue fibrosis proposition.

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