Medicament for treating tristimania and preparation method thereof

Abstract

The invention discloses a medicament for treating tristimania and a preparation method thereof. The method comprises the following steps of: cutting a medicinal material, namely hypericum perforatum, performing refluxing extraction on the cut hypericum perforatum for three times by using 30 to 80 percent ethanol or 30 to 100 percent methanol, reclaiming a solvent, and concentrating; adding water and ethanol into the extract to dilute the extract until the weight of the extract is 3 to 7 times that of the medicinal material, adjusting until the alcohol content is 0 to 20 percent, uniformly mixing and centrifuging; making the supernatant pass through a treated macroporous adsorption resin column, and stopping sampling after resin adsorption is saturated; eluting with water until the eluate is clear and removing the washing liquor; eluting with 50 to 90 percent ethanol, collecting the eluate, reclaiming the ethanol, concentrating the product, and performing spray drying to obtain a hypericum perforatum extract; and adding conventional auxiliary materials into the hypericum perforatum extract and preparing clinically acceptable formulations, such as tablets, capsules, pills, particles and the like by the conventional process.

Description

technical field [0001] The invention relates to a medicine and a preparation method thereof, in particular to a hypericum perforatum extract for treating depression and a preparation method thereof. Background technique [0002] Depression is a human emotional disease, which is chronic and recurrent, with diverse symptoms, such as depression, appetite and sleep disorders, world-weariness and suicidal tendencies. As people's pace of life accelerates, social competition intensifies, and population aging accelerates, depression has become an important disease that endangers public health. According to WHO statistics, patients with depression in the world account for 3% of the total population. The incidence of depression in my country has grown from 3.6‰ in the 1970s to 7.6‰ today, and about 30-70% are misdiagnosed as neurasthenia. In big cities such as Beijing and Shanghai, the incidence rate is as high as 3.43%, and the incidence rate is increasing year by year. People with ...

AI Technical Summary

Problems solved by technology

① Drugs, because of many side effects and high toxicity, have been eliminated

In order to reduce side effects and reduce toxicity, some non-tricyclic antidepressants appeared in the 1970s, such as maprotiline, etc., but the side effects have not been completely overcome

③ Drugs, whose pharmacological feature is to specifically block the reuptake of serotonin, have a very low affinity for other neurotransmitter receptors in the brain, and have less toxic side effects than tricyclic drugs, but still have certain side effects

In a word, existing medicines all have some disadvantages: large side effects, high incidence rate, single mechanism of action, high price, easy recurrence, etc., which have seriously affected their popularization and use.

Existing products cannot meet the demand, therefore, the development of new, high-efficiency, broad-spectrum, low-toxic antidepressants has become one of the research and development directions of pharmaceutical companies in various countries

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