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Partially-degradable composite material for intrauterine device (IUD)

An intrauterine device and composite material technology, applied in the field of intrauterine device materials, can solve the problems of no breakthrough progress, sharp, small release rate IUD service life and other issues in Science magazine in 2002

Inactive Publication Date: 2011-04-20
HUAZHONG UNIV OF SCI & TECH
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The Science magazine in 2002 pointed out that the research on birth control reached its peak in the 1950s and 1960s, but there has been no breakthrough since the invention of the contraceptive pill.
The higher release rate of copper ions at the initial stage of implantation may increase side effects such as pain and bleeding at the initial stage of implantation, while the lower release rate at the later stage becomes a key factor restricting the service life of composite IUDs

Method used

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  • Partially-degradable composite material for intrauterine device (IUD)
  • Partially-degradable composite material for intrauterine device (IUD)
  • Partially-degradable composite material for intrauterine device (IUD)

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] Weigh 25g of nano-copper particles and 75g of medical-grade low-density polyethylene (LDPE), and prepare Cu / LDPE composites without adding biodegradable biomaterials by premixing, blending, pressure injection or injection molding.

Embodiment 2

[0021] Weigh 25g of micron copper particles, 72.5g of medical grade low-density polyethylene (LDPE), 2.5g of polylactic acid (PLA), and prepare polylactic acid (PLA) added by premixing, blending, injection or injection molding. Cu / LDPE composite material.

[0022] Examples 3-18 were all prepared by a method similar to that of Example 1 and Example 2, wherein the composition of the prepared partially degradable Cu / LDPE composite material for IUD is shown in Table 1.

[0023] The composition of composite material for IUD in each embodiment of table 1

[0024]

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PUM

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Abstract

The invention discloses a partially-degradable composite material for an intrauterine device (IUD). The composite material comprises copper particles, low-density polyethylene and a degradable biological material; the weight of the degradable biological material is 0.5-30% (preferably 5.0-20%) of the total weight of the composite material for the IUD; and the degradable biological material is any one of polylactic acid, polyglycolide and poly (L-lactide). The composite material IUD prepared from the composite material for the IUD has the advantages that on the premise of keeping the Cu<2+> content constant, the Cu<2+> release rate at the early implantation stage can be reduced, the Cu<2+> release rate at the late implantation stage can be improved and the side reactions such as pain and bleeding at the early implantation stage of the composite material IUD prepared from the composite material can be lightened, and the service life of the composite material IUD can be prolonged.

Description

technical field [0001] The present invention relates to a kind of intrauterine device material, in particular to a partially degradable intrauterine device material, which is loaded with polylactic acid ( PLA) or polyglycolide (PGA) or polyglycolide (PLGA) and other degradable biomaterials. technical background [0002] Intrauterine Device (IUD) is the most widely used birth control method in the world. Human Reproduction Update, the top publication in the field of obstetrics and gynecology, and the famous American medical journal Lancet both strongly recommend the copper-containing intrauterine device (Cu-IUD), pointing out that its contraceptive effect is comparable to tubal ligation, but it is relatively simpler, safer, cheaper and more reversible. Among the 230 million women of childbearing age who use various contraceptive measures in my country, there are 114 million IUD users, 95% of whom are Cu-IUD users. However, Cu-IUD has been unable to solve clinical side effe...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L31/14A61L31/06
Inventor 夏先平谢长生田宽蔡水洲
Owner HUAZHONG UNIV OF SCI & TECH
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