Therapeutic agent for tympanites in ruminant animal

A technology of a therapeutic agent and a treatment method, which is applied in animal feed, animal feed, medical raw materials derived from subphylum angiosperms, etc., can solve the problems of small effect, complicated and incomplete cure, and achieve the effect of preventing recurrence.

Inactive Publication Date: 2011-08-24
IDEMITSU KOSAN CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

We consider physical symptomatic treatment (deflation, defoaming, use of rumination-promoting materials) to be a temporary treatment that does not address the root cause and is not a complete cure
In particular, the above-mentioned chronic bloat is in a state where fermented gas is easily generated and accumulated, so these symptomatic treatments have little effect
In addition, deflation requires a lot of labor and is more complicated because the operation of inserting the injection needle from the outer skin to extract the gas, or extracting the gas from the oral or nasal cannula, and the animal will also have a greater stress response
In addition, there are antibiotics that have a bactericidal effect on Streptococcus bovis, but no effective substance has been practically used as a therapeutic agent
[0006] Cashew nut shell oil is known to have an antibacterial effect (non-patent document 1) and an effect of reducing coccidium disease (patent document 1), but there is no knowledge about the therapeutic effect of bloat in ruminants

Method used

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Examples

Experimental program
Comparison scheme
Effect test

manufacture example

[0066] 500 kg of cashew nut shells were obtained from Kashiyuichi Toray Ding Co., Ltd., and 158 kg of cashew nut shell oil was produced by pressing. In addition, a heat-treated cashew nut shell liquid in which anacardic acid was converted into cardanol by heat treatment at 130° C. was obtained from Kasyu Treying Co., Ltd.

[0067] The composition of cashew nut shell liquid was determined by the following method. That is, using HPLC (Waters600, Japan Woots Co., Ltd.), detector (Waters490E, Japan Woots Co., Ltd.), printer (Cromatpack C-R6A, Shimadzu Corporation), chromatography Column (SUPELCOSIL LC18, SUPELCO). Acetonitrile: water: acetic acid solvent with a ratio of 80:20:1 (volume ratio) was used, and the flow rate was 2 ml / min. Absorbance at 280 nm was detected.

[0068] Non-heated cashew nut shell liquid contains 61.8% by mass of anacardic acid, 8.2% by mass of cardanol, and 19.9% ​​by mass of cardanol, and the heated cashew nut shell liquid contains 0.0% by mass of anac...

Embodiment 1

[0070] Male Holland cows (Holstein) that repeatedly produced chronic gas and were treated with an antifoaming agent about 10 times but did not improve their symptoms were used for the test. The cattle used in the experiment were 6 months old and weighed about 300kg. In the test, the administration start date was regarded as day 0. 50 ml of cashew nut shell liquid was put into a 60 ml syringe without a needle (product of Terumo Co., Ltd.). The administration adopts forced oral administration, and the volume of the administered liquid is adjusted through the scale of the syringe. Then, dosing according to the schedule in Table 1.

[0071] [Table 1]

[0072] number of days

Dosage

Bloat Index*

day 0

100ml

3

Day 1

50ml

1

day 2

40ml

1

Day 3

40ml

0

day 4

40ml

0

[0073] *The bloating index is displayed in four stages according to the degree of bloating

[0074] (0: no swelling...

Embodiment 2

[0077] Female Dutch cows whose gas generation was temporarily cured by gas perforation for deflation five days before the start of the test but were found to be gas again were used for the experiment. The cattle used in the experiment were 2 months old and weighed about 100kg. In the test, the administration start date was regarded as day 0. In the same manner as in Example 1, cashew nut shell liquid was forcibly administered orally. As described in Table 2, for the purpose of confirming the effective dosage, the dosage was gradually increased from a lower dosage than in Example 1.

[0078] [Table 2]

[0079] number of days

Dosage

Bloat Index*

day 0

10ml

1

[0080] Day 1

20ml

2

day 2

30ml

2

Day 3

30ml

1

day 4

30ml

1

day 5

40ml

1

day 6

40ml

0

day 7

40ml

0

[0081] *The bloating index is displayed in four stages acc...

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PUM

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Abstract

A therapeutic agent for tympanites in a ruminant animal, which is characterized by comprising a cashew nut shell oil, a heat-treated cashew nut shell oil, anacardic acid, cardanol, or a combination of anacardic acid and cardanol.

Description

technical field [0001] The present invention relates to a bloat treatment agent containing cashew nut shell liquid, heat-treated cashew nut shell liquid, anacardic acid, cardanol, or simultaneously containing anacardic acid and cardanol. Background technique [0002] Bloat is a disease that occurs in ruminants such as cows and sheep, and it is believed that one of the causes is difficulty in expulsion of the gas produced by the fermentation of the first stomach. Ruminants suffering from bloat, due to the accumulation of fermented gas, exhibit abnormal hypertrophy of the first stomach volume or decreased feeding activity, decreased rumination behavior, difficulty in breathing, etc., and will be fatal in severe cases. And it is known that bloat has both acute and chronic forms. In the case of acute bloat, the symptoms deteriorate very quickly, and death often occurs due to dyspnea. On the other hand, in the case of chronic bloat, since the fermented gas becomes chronic, the ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/05A23K1/16A23K1/18A61K31/60A61K36/18A61P1/00A61K36/00A61K36/22A61P31/04
CPCA61K31/05A23K1/164A61K36/18A61K31/60A61K36/22A23K1/1813A23K1/1612A23K20/111A23K20/158A23K50/10A61P1/00A61P1/14A61P3/00A61P31/04A61K2300/00
Inventor 铃木千枝长岛协望月正己
Owner IDEMITSU KOSAN CO LTD
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