Therapeutic agent for tympanites in ruminant animal
A technology of a therapeutic agent and a treatment method, which is applied in animal feed, animal feed, medical raw materials derived from subphylum angiosperms, etc., can solve the problems of small effect, complicated and incomplete cure, and achieve the effect of preventing recurrence.
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manufacture example
[0066] 500 kg of cashew nut shells were obtained from Kashiyuichi Toray Ding Co., Ltd., and 158 kg of cashew nut shell oil was produced by pressing. In addition, a heat-treated cashew nut shell liquid in which anacardic acid was converted into cardanol by heat treatment at 130° C. was obtained from Kasyu Treying Co., Ltd.
[0067] The composition of cashew nut shell liquid was determined by the following method. That is, using HPLC (Waters600, Japan Woots Co., Ltd.), detector (Waters490E, Japan Woots Co., Ltd.), printer (Cromatpack C-R6A, Shimadzu Corporation), chromatography Column (SUPELCOSIL LC18, SUPELCO). Acetonitrile: water: acetic acid solvent with a ratio of 80:20:1 (volume ratio) was used, and the flow rate was 2 ml / min. Absorbance at 280 nm was detected.
[0068] Non-heated cashew nut shell liquid contains 61.8% by mass of anacardic acid, 8.2% by mass of cardanol, and 19.9% by mass of cardanol, and the heated cashew nut shell liquid contains 0.0% by mass of anac...
Embodiment 1
[0070] Male Holland cows (Holstein) that repeatedly produced chronic gas and were treated with an antifoaming agent about 10 times but did not improve their symptoms were used for the test. The cattle used in the experiment were 6 months old and weighed about 300kg. In the test, the administration start date was regarded as day 0. 50 ml of cashew nut shell liquid was put into a 60 ml syringe without a needle (product of Terumo Co., Ltd.). The administration adopts forced oral administration, and the volume of the administered liquid is adjusted through the scale of the syringe. Then, dosing according to the schedule in Table 1.
[0071] [Table 1]
[0072] number of days
Dosage
Bloat Index*
day 0
100ml
3
Day 1
50ml
1
day 2
40ml
1
Day 3
40ml
0
day 4
40ml
0
[0073] *The bloating index is displayed in four stages according to the degree of bloating
[0074] (0: no swelling...
Embodiment 2
[0077] Female Dutch cows whose gas generation was temporarily cured by gas perforation for deflation five days before the start of the test but were found to be gas again were used for the experiment. The cattle used in the experiment were 2 months old and weighed about 100kg. In the test, the administration start date was regarded as day 0. In the same manner as in Example 1, cashew nut shell liquid was forcibly administered orally. As described in Table 2, for the purpose of confirming the effective dosage, the dosage was gradually increased from a lower dosage than in Example 1.
[0078] [Table 2]
[0079] number of days
Dosage
Bloat Index*
day 0
10ml
1
[0080] Day 1
20ml
2
day 2
30ml
2
Day 3
30ml
1
day 4
30ml
1
day 5
40ml
1
day 6
40ml
0
day 7
40ml
0
[0081] *The bloating index is displayed in four stages acc...
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