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Method for extracting and purifying amygdalin from peach seeds

A kind of technology of amygdalin and peach kernel, which is applied in the field of extraction and purification of amygdalin, can solve the problems of low purity of amygdalin and high purification cost, and achieve the effects of environmentally friendly large-scale production, low cost, and easy large-scale production

Inactive Publication Date: 2011-11-09
EAST CHINA UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The purpose of the present invention is to provide a method for purifying amygdalin from peach kernels, which overcomes the defects in the prior art that the purification cost of amygdalin is relatively high and the purity of amygdalin is not high

Method used

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  • Method for extracting and purifying amygdalin from peach seeds
  • Method for extracting and purifying amygdalin from peach seeds

Examples

Experimental program
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Effect test

Embodiment 1

[0018] 48 grams of peach kernels (commercially available) and 480 grams of ethanol solution with a concentration of 70v / v% are placed in a round-bottomed flask with a heating device and a condenser, heated to reflux, and kept under reflux (extraction) After 2.5 hours, filter, and concentrate the resulting filtrate under reduced pressure to obtain 48 g of a concentrate.

[0019] 12 milliliters of HZ-818 macroporous resin (produced by Shanghai Huazhen Technology Trading Co., Ltd.) through pretreatment (see [J] Strait Pharmacy. 2007, 19 (9): 96-99. for the specific steps of pretreatment) into the inner diameter The HZ-818 macroporous resin adsorption column is formed in a glass tube with a height of 10 mm and a height of 400 mm.

[0020] Under normal pressure (1 atmosphere) and 10°C to 35°C (preferably 20°C to 25°C), the concentrated solution obtained in the above-mentioned reflux extraction step is drawn from one end of the HZ-818 macroporous resin adsorption column (usually the...

Embodiment 2

[0023] 2 kg of peach kernels (commercially available) and 20 kg of ethanol solution with a concentration of 50v / v% are placed in a round-bottomed flask with a heating device and a condenser, heated to reflux, and kept under reflux (extraction) After 1.5 hours, filter, and concentrate the obtained filtrate under reduced pressure to obtain 2 kg of concentrated solution.

[0024] 500 milliliters of HZ-818 macroporous resin (produced by Shanghai Huazhen Technology Trading Co., Ltd.) through pretreatment (see [J] Strait Pharmacy. 2007, 19 (9): 96-99.) The HZ-818 macroporous resin adsorption column is formed in a glass tube with a height of 60 mm and a height of 800 mm.

[0025] Under normal pressure (1 atmosphere) and 10°C to 35°C (preferably 20°C to 25°C), the concentrated solution obtained in the above-mentioned reflux extraction step is drawn from one end of the HZ-818 macroporous resin adsorption column (usually the upper end) ) is added, adsorbed by HZ-818 macroporous resin, ...

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Abstract

The invention relates to a method for extracting and purifying amygdalin from peach seeds. The invention provides a method for extracting and purifying the amygdalin by combining a method for heat extraction by use of an ethanol solution with a method for absorption and desorption by use of macroporous absorption resin, and the method has a remarkable advantage that the purity of the obtained amygdalin is higher (more than 60%). Furthermore, the method for extraction and purification provided by the invention further has the advantages of low cost, environment friendliness, easiness in mass production and the like.

Description

technical field [0001] The invention relates to a method for extracting and purifying amygdalin, in particular to a method for extracting and purifying amygdalin from peach kernels. Background technique [0002] Peach kernel is the dry mature seed of peach (Prunus persica (L.) Batsch) or mountain peach (Prunus davidiana (Carr.) Franch) of Rosaceae. Its main active ingredient is amygdalin, and its molecular structure is composed of a unit of benzaldehyde, Composed of one unit of hydrocyanic acid and two units of glucose, it has the effects of eliminating phlegm and relieving cough, and auxiliary anticancer effects. It has become a commonly used expectorant and antitussive agent and auxiliary anticancer drug in medicine. [0003] However, after amygdalin is decomposed by digestive enzymes, a large amount of hydrocyanic acid is produced, which inhibits intracellular respiration and stops the cell oxidation reaction, which leads to tissue suffocation, intracellular hypoxia, and ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07H15/18C07H1/08
Inventor 胡坪王帅张敏章弘扬王月荣
Owner EAST CHINA UNIV OF SCI & TECH
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