Kit used for diagnosing acute exacerbation period of chronic obstructive pulmonary disease

A technology for chronic obstructive pulmonary disease and acute exacerbation, applied in the biological field, can solve the problem of incomplete understanding of the pathogenesis of chronic obstructive pulmonary disease, and achieve the effect of simple, easy and reliable protein expression level.

Inactive Publication Date: 2011-11-23
ZHONGSHAN HOSPITAL FUDAN UNIV
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Problems solved by technology

[0003] The pathogenesis of chronic obstructi

Method used

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  • Kit used for diagnosing acute exacerbation period of chronic obstructive pulmonary disease

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Embodiment

[0017] A kit for diagnosing the acute exacerbation of chronic obstructive pulmonary disease, comprising the following reagents:

[0018] 1. Interleukin 9 (manufactured by American R&D Systems, model MAB209) and its enzyme-labeled antibody (manufactured by American R&D Systems, model BAF209);

[0019] 2. Macrophage-derived chemokine (manufactured by American R&D Systems, model MAB336) and its enzyme-labeled antibody (manufactured by American R&D Systems, model BAF336);

[0020] 3. Interleukin-18 binding protein A (produced by R&D Systems, USA, model MAB1192) and its enzyme-labeled antibody (produced by R&D Systems, USA, model BAF119);

[0021] 4. C-C sequence ligand 28 (produced by R&D Systems, USA, model MAB7171) and its enzyme-labeled antibody (produced by R&D Systems, USA, model BAF717);

[0022] 5. Monocyte chemoattractant protein-3 (manufactured by American R&D Systems, model MAB282) and its enzyme-labeled antibody (manufactured by American R&D Systems, model BAF282);

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Abstract

The invention relates to a kit used for diagnosing the acute exacerbation period of chronic obstructive pulmonary disease. The kit comprises a cell factor and an enzyme labeled antibody thereof and is characterized in that the cell factor is interleukin 9, interleukin 18 binding protein A, C-C sequence ligand 28, a human skin T cell capture chemokine, a Beta cytokine, a monocyte chemoattractant protein-3, a monocyte chemoattractant protein-4, a lymphotoxin induced protein entering the T cell, a macrophage-derived chemokine, a human bone marrow suppression factor 1, a human macrophage stimulating protein, an osteopontin and a human thymus expressed chemokine. The invention firstly proposes that the cell factor can be used as a leading indicator for diagnosis of the acute exacerbation period of the chronic obstructive pulmonary disease.

Description

technical field [0001] The invention relates to a kit for diagnosing acute exacerbation of chronic obstructive pulmonary disease, which belongs to the field of biotechnology. Background technique [0002] Chronic obstructive pulmonary disease (COPD) is a lung disease characterized by persistent obstruction of airflow from the lungs. The disease is an underdiagnosed, life-threatening lung disease that impedes normal breathing and is not fully reversible. Its main clinical manifestations are cough, sputum production and dyspnea. As the course of the disease progresses, it can develop to also feel short of breath when walking on a flat road. Some patients have wheezing symptoms. In addition, there are systemic symptoms such as fatigue, anorexia, and weight loss. Respiratory failure or heart failure may cause corresponding symptoms during the acute attack. Because of its large number of patients, high mortality rate and heavy social and economic burden, it has become an im...

Claims

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Application Information

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IPC IPC(8): G01N33/68G01N33/577
Inventor 白春学王向东陈弘
Owner ZHONGSHAN HOSPITAL FUDAN UNIV
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