Application of rapamycin in the treatment of early brain injury of subarachnoid hemorrhage

A subarachnoid, rapamycin technology, applied in cardiovascular system diseases, nervous system diseases, drug combinations, etc., to achieve the effects of enhancing autophagy, reducing EBI, and reducing cerebral edema

Inactive Publication Date: 2011-12-14
THE FIRST AFFILIATED HOSPITAL OF SOOCHOW UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, at this stage, no one has studied the intervention of aut

Method used

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  • Application of rapamycin in the treatment of early brain injury of subarachnoid hemorrhage
  • Application of rapamycin in the treatment of early brain injury of subarachnoid hemorrhage
  • Application of rapamycin in the treatment of early brain injury of subarachnoid hemorrhage

Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0030] 1. Materials:

[0031] 1.1 Reagents and experimental equipment

[0032] 1.1.1 Main Drugs and Reagents

[0033] Rapamycin (RAP) (purchased from Sigma-aldrich, USA), 3-MA (purchased from Sigma-aldrich, USA), Evans blue (purchased from Shanghai Baoman Biotechnology Co., Ltd.), 50% trichloroacetic acid ( TCA), absolute ethanol, etc.

[0034] 1.1.2 Main Instruments

[0035] Electronic scale (FA2004B Shanghai Yueping Technology Instrument Co., Ltd.), oven (DHG9070B Shanghai Langgan Experimental Equipment Co., Ltd.), homogenizer (985-370 BIOSPEC PRODUCTS, INC), centrifuge (GL-16A Shanghai Fischer Analytical Instrument Co., Ltd. company), spectrophotometer (UV-757 Shanghai Mapoda Instrument Co., Ltd.), stereotaxic instrument (ALCB10 Shanghai Alcott Biotechnology Co., Ltd.), 5-μL micro sample injector (Shanghai Gaoge Industry and Trade Co., Ltd. )Wait

[0036] 1.2 Experimental animals

[0037] Adult healthy male Sprague-Dawley (S-D) rats were provided by the Experimental A...

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Abstract

The invention discloses an application of rapamycin of formula (I) in the preparation of a pharmaceutical composition for treating early brain injury after subarachnoid hemorrhage. The present invention proves through experiments that RAP can enhance autophagy, reduce brain edema, reduce the permeability of the blood-brain barrier and alleviate clinical symptoms, thereby alleviating EBI after SAH, and then protecting the brain tissue, providing a basis for the treatment of EBI after SAH A new approach to treatment.

Description

technical field [0001] The invention belongs to the technical field of medicine preparation, and in particular relates to the application of rapamycin in treating early brain injury of subarachnoid hemorrhage. Background technique [0002] Subarachnoid hemorrhage (SAH) refers to the flow of blood into the subarachnoid space after intracranial blood vessel rupture. Subarachnoid hemorrhage is generally divided into two categories: brain injury and non-injury (spontaneous). Flowing into the subarachnoid space is called primary subarachnoid hemorrhage; 2. Due to intraparenchymal hemorrhage, blood penetrates the brain tissue and enters the subarachnoid space, which is called secondary subarachnoid hemorrhage. Spontaneous SAH is a fatal disease with a mortality rate as high as 32%-67%, of which aneurysmal SAH accounts for more than 85%. Over the past few decades, rerupture hemorrhage and cerebral vasospasm have been considered to affect SAH patients An important prognostic facto...

Claims

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Application Information

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IPC IPC(8): A61K31/436A61P9/00A61P25/00
Inventor 王中陈罡石晓勇
Owner THE FIRST AFFILIATED HOSPITAL OF SOOCHOW UNIV
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