New application of isosorbide mononitrate

A technology of isosorbide dinitrate and application, applied in the field of medicine, can solve the problems of increasing endometrial uterine glands and the like

Inactive Publication Date: 2011-12-21
SICHUAN WEIXIN MEDICAL TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] At present, there are no related reports on the use of isosorbide mononitrate to increase the thickness of the

Method used

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  • New application of isosorbide mononitrate
  • New application of isosorbide mononitrate
  • New application of isosorbide mononitrate

Examples

Experimental program
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Embodiment 1

[0027] The preparation of embodiment 1 suppository

[0028] Table 1

[0029]

[0030] Note: ①Each suppository contains 2.88mg of ISMN.

[0031] ②P-188 is poloxamer 188.

[0032] ③The suppository is bullet-shaped, with a particle size of 4mm. Among them, the length of semi-synthetic fatty acid glyceride: 5mm; the length of glycerin gelatin and P-188: 4mm.

[0033] Suppository preparation: according to the No. 1-12 formula in Table 1, enlarge the feeding by 30-100 times, weigh the matrix in Table 1 and place it in an evaporator, heat it on a water bath, stop heating when 2 / 3 of the matrix melts, and stir to make Complete melting; measure the penetration aid (azone and / or propylene glycol) in Table 1, and weigh the finely ground ISMN powder (through a 100-mesh sieve) at the same time, add it to the molten matrix in stages, and keep stirring to make the drug evenly dispersed , when the mixture is in a viscous state, pour it into a mold coated with lubricant, cut off the ove...

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Abstract

The invention belongs to the field of medicine, and in particular relates to a new application of isosorbide mononitrate and a new dosage form corresponding to the new application; specifically, it is the preparation of isosorbide mononitrate in the preparation of drugs for promoting endometrium development use. The promotion of endometrial development is specifically achieved by repairing and improving the endometrium to increase the thickness of the endometrium, or by promoting the development of uterine glands, or by promoting the development of uterine stroma. The drug prepared to adapt to the above four new uses is a topical vaginal administration preparation, that is, a preparation prepared by adding an effective amount of isosorbide mononitrate as an active ingredient and adding pharmaceutically acceptable auxiliary materials. After vaginal administration of isosorbide mononitrate, it can not only promote the development of endometrium tissue and improve the endometrial receptivity, but also effectively avoid the side effect of isosorbide mononitrate blood pressure drop. A new option is provided.

Description

[0001] This application is a divisional application of the invention patent application with the application number: 200910307703.8, the invention name: the new application of isosorbide mononitrate, and the application date is September 25, 2009. technical field [0002] The invention belongs to the field of medicine, and specifically relates to a new application of isosorbide mononitrate and a corresponding new dosage form adapted to the new application. Background technique [0003] One of the keys to the successful implantation of fertilized eggs is that the state of endometrial receptivity (uterine receptivity) is synchronized with the development of fertilized eggs. Endometrial receptivity is a comprehensive state in which the endometrium accepts embryo implantation, including the thickness of the endometrium, the developmental state of the glands and stroma, and the blood supply state of the endometrium. [0004] According to the statistics of the United States, 15% o...

Claims

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Application Information

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IPC IPC(8): A61K31/34A61P15/08A61P15/00
Inventor 高翔
Owner SICHUAN WEIXIN MEDICAL TECH
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