A method for extracting propolis containing high-purity flavonoids

An extraction method and technology of flavonoids, applied in the field of propolis extraction containing high-purity flavonoids, can solve the problems of undiscovered flavonoids, complicated operation, low quality, etc. safe effect

Inactive Publication Date: 2011-12-21
张大辉
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0100] 5.2 Soxhlet extraction: The Soxhlet extraction method uses a Soxhlet extractor to add an organic solvent to accelerate the extraction, which is more efficient than traditional water-soluble extraction, but generally takes several hours or more than ten hours, and is high temperature, low quality,

Method used

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Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0317] One of the preparation methods of propolis extract:

[0318] (1) Preparation of propolis extract crude product

[0319] The propolis raw material is heated and impregnated with 95% ethanol, heated and decolorized with activated carbon + activated clay, cooled, filtered or centrifuged, the supernatant is concentrated and recovered, spray-dried and pulverized to obtain a crude propolis extract;

[0320] (2) Refined propolis extract

[0321] Dissolve the crude product of propolis extract with ethanol, add hydrochloric acid to hydrolyze it to obtain flavonoid aglycone, concentrate to extract, dissolve the extract with more than 80% ethanol, filter or centrifuge, concentrate and recover the supernatant, spray dry and pulverize, and obtain refined propolis extract;

[0322] The preparation method two of propolis extract:

[0323] (1) Preparation of propolis extract crude product

[0324] The propolis raw material is heated and impregnated with 75% ethanol, after ultrasoni...

Embodiment 1

[0340] (1) Preparation of propolis extract crude product

[0341] 1000g of propolis raw material was heated and impregnated with 75% ethanol, after ultrasonic treatment, allowed to cool, filtered or centrifuged, the supernatant was concentrated and recovered, spray-dried and pulverized to obtain 445g of crude propolis extract;

[0342] (2) Refined propolis extract

[0343] Dissolve 445g of propolis extract crude product in 95% ethanol, add hydrochloric acid to hydrolyze to obtain flavonoid aglycone, concentrate to extract, extract extract is dissolved in more than 80% ethanol, filter or centrifuge, concentrate and recover the supernatant, spray dry and pulverize , obtain refined propolis extract 293g, flavonoid content 9.2%, lead content 0.013mg / Kg.

Embodiment 2

[0345] (1) Preparation of propolis extract crude product

[0346] 1000g of propolis raw material was heated and impregnated with 85% ethanol, after microwave treatment, allowed to cool, filtered or centrifuged, the supernatant was concentrated and recovered, spray-dried and pulverized to obtain 456g of crude propolis extract;

[0347] (2) Refined propolis extract

[0348] Dissolve 456g of crude propolis extract in 95% ethanol, hydrolyze with hydrochloric acid to obtain flavonoid aglycone, concentrate to the extract, dissolve the extract in more than 80% ethanol, filter or centrifuge, concentrate and recover the supernatant, spray dry and pulverize , obtain refined propolis extract 310g, flavonoid content 9.8%, lead content 0.014mg / Kg.

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PUM

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Abstract

The invention relates to the technical fields of medicine, food, beverage, etc., in particular to a method for extracting propolis containing high-purity flavonoids, that is, a propolis processing method that ensures low content of heavy metals, high content of flavonoids, and maintains the "original flavor" of the product . The invention studies the preparation method of propolis in a targeted manner, and the obtained propolis extract is safe, low in toxicity, stable in properties, strong in pharmacological action, wide in application range, strong in practicability, and remarkable in preventing and health care effects of various diseases. The method has the advantages of low cost, simple preparation process, high yield of active ingredients, high content of flavonoid extract, and much lower heavy metals than other methods, especially the lead content is far lower than the international standard, and the quality of the prepared preparation is stable , easy to operate and more suitable for industrial production. The invention provides a new source of propolis extract, perfects the existing propolis preparation quality assurance system, and has important value for improving the existing preventive health care level.

Description

technical field [0001] The present invention relates to technical fields such as medicine, food, beverage, specifically relates to a kind of processing technology of medicine, health product or food, more specifically relates to a kind of propolis extraction method that contains high-purity flavonoids component, more specifically It is said that it relates to a propolis processing method that still maintains the "original flavor" of the product under the premise of ensuring low content of heavy metals and high content of flavonoids. Background technique [0002] (1) Research overview of propolis [0003] 1 Overview [0004] Propolis, along with honey and royal jelly, are natural substances produced by bees. It was first found at the entrance of the hive, hence the name. [0005] Propolis is a kind of colloidal solid with aromatic smell ( Aromatic jelly). Propolis is an effective substance used by bees to maintain the health of the whole group. 40,000 to 50,000 bees can o...

Claims

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Application Information

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IPC IPC(8): A61K35/64A23L1/076A61P3/06A61P3/10A61P29/00A61P31/00A61P37/08A61P35/00A61P39/02A61P33/00A61P1/16A61P9/00A61P7/02A23L21/20A61K35/644
Inventor 张大辉戴沛韩婷管孝君
Owner 张大辉
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