Improved diagnosis of liver fibrosis or cirrhosis

A pathological and individual technology, which is applied in medical automated diagnosis, diagnosis, and acoustic wave diagnosis, etc., can solve problems such as the difficulty of clinical application of multi-step sequential algorithms, and achieve the effects of improving diagnostic accuracy, high industrial benefits, and increasing accuracy

Inactive Publication Date: 2012-01-25
UNIV DANGERS +1
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Problems solved by technology

However, the clinical application of thes...

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  • Improved diagnosis of liver fibrosis or cirrhosis
  • Improved diagnosis of liver fibrosis or cirrhosis
  • Improved diagnosis of liver fibrosis or cirrhosis

Examples

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Embodiment 1

[0082] Blood fibrosis detection and by sonographic elastometry (such as Fibroscan TM ) correlates well with the histological stage of fibrosis. In this paper, we aim to improve the non-invasive diagnosis of liver fibrosis stages through an innovative combination of blood tests and Fibroscan.

[0083] Methods: 349 patients with chronic hepatitis C at three medical centers participated in the study. For each patient, a liver biopsy and the following fibrosis assays were performed: Fibroscan (FS), Fibrotest, FibroMeter (FM, for significant fibrosis or cirrhosis), Hepascore, Fib4, and APRI. The reference for liver fibrosis is the Metavir F grade. Fibrosis detection independently associated with significant fibrosis (F > 2) or sclerosis (F4) was determined by stepwise binary logistic regression replicated on 1000 bootstrap samples of 349 patients.

[0084] RESULTS: Prevalence of diagnostic targets: significant fibrosis: 67.9%, cirrhosis: 11.8%. Multivariate analysis on 1000 boo...

Embodiment 2

[0131] patient

[0132] 390 patients with chronic liver disease (CLD) hospitalized for percutaneous liver biopsy at the University Hospitals of Angers and Bordeaux (France) participated in the study. 194 patients were at the experimental site in Angers from April 2004 to June 2007 (group A, exploratory group), and 196 patients were at the experimental site in Bordeaux from September 2003 to April 2007 (group B , effective group). Patients with the following cirrhotic complications were excluded: ascites, bleeding from esophageal varices, systemic infection, and liver cancer. Non-invasive assessment of liver fibrosis by blood fibrosis assay and LSE was performed within one week prior to liver biopsy.

[0133] method

[0134] Histological liver fibrosis assessment

[0135]Percutaneous liver biopsy was performed using the Menghini technique with a 1.4-1.6 mm diameter needle. At each experimental site, liver biopsies were assessed by Metavir grades (with consensus interpret...

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Abstract

This invention relates to method of diagnosing the presence and/or severity of a liver pathology and/or of monitoring the effectiveness of a curative treatment against a liver pathology in an individual, leading to a score, comprising the combination, of at least one blood test and of at least one data issued from a physical method of diagnosing liver fibrosis, said data being selected from the group consisting of medical imaging data and clinical measurements, said combination being performed through a mathematical function.This invention also relates to a method wherein the combination through a mathematical function, of at least one blood test and of at least one data issued from a physical method of diagnosing liver fibrosis, is performed at least twice and the at least two resulting scores are combined in an algorithm based on the diagnostic reliable intervals.

Description

technical field [0001] The present invention relates to an improved method for the diagnosis of liver fibrosis or cirrhosis by applying to an individual, especially those suffering from a disease associated with marked or severe fibrosis or cirrhosis, the A combination of at least one blood test and at least one physical method is implemented. The method of the present invention involves a score known as the SF or C-index, optionally a combination thereof. Background technique [0002] Liver biopsy is the traditional method used to diagnose liver disease in patients. However, since liver biopsy is invasive and expensive, non-invasive biopsy of liver fibrosis has received considerable attention in the last decade as an alternative to liver biopsy. The first generation of simple blood fibrosis assays combined conventional indirect blood markers into simple ratios, such as APRI (5) or more recently FIB-4 (6). Second-generation computational tests combine indirect and / or dire...

Claims

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Application Information

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IPC IPC(8): G06F19/00
CPCA61B8/485A61B8/08A61B5/416G06F19/345A61B5/4244G16H50/20
Inventor 保罗·卡乐斯J·布尔西耶
Owner UNIV DANGERS
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