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Application of qi-tonifying dripping pill containing radix astragali and root of red-rooted salvia to preparation of medicament for improving myocardial fibrosis and myocardial hypertrophy

A technique for Qishen Yiqi Dropping Pills and myocardial fibrosis, which is applied in the field of medical applications to achieve the effects of improving symptoms and improving conditions.

Inactive Publication Date: 2012-03-14
TIANJIN TASLY PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] Previous studies have shown that the active ingredients of Astragalus have a certain inhibitory effect on myocardial fibrosis, which may be related to the inhibition of TGF-β1 expression

Method used

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  • Application of qi-tonifying dripping pill containing radix astragali and root of red-rooted salvia to preparation of medicament for improving myocardial fibrosis and myocardial hypertrophy
  • Application of qi-tonifying dripping pill containing radix astragali and root of red-rooted salvia to preparation of medicament for improving myocardial fibrosis and myocardial hypertrophy
  • Application of qi-tonifying dripping pill containing radix astragali and root of red-rooted salvia to preparation of medicament for improving myocardial fibrosis and myocardial hypertrophy

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0112]Take 86.5g of astragalus, 21.3g of salvia miltiorrhiza, 3.5g of notoginseng, 20.6g of jiangxiang, and 30g of polyethylene glycol-6000 as an auxiliary material. Decoct the crushed salvia miltiorrhiza and Panax notoginseng in water twice, adding 7 times the amount of water each time for 2 hours each time, combining the decoction liquid, filtering, and concentrating the filtrate to 900ml, adding 95% ethanol to make the alcohol concentration reach 70%, let it stand for 12-24 hours, filter, recover ethanol, concentrate into an extract with a relative density of 1.32-1.38 (50-60°C); decoct the pulverized Astragalus membranaceus twice with water, adding 6 Double the amount of water, extract for 2 hours and 1 hour in turn, combine the filtrate, and when concentrated to about 1500ml, add 95% ethanol to make the alcohol concentration 60%, let it stand for 12-24 hours, filter, recover ethanol from the filtrate, and concentrate to about 400ml , add 95% ethanol to make the alcohol co...

Embodiment 2

[0114] Get Astragalus 40.6g, Salvia miltiorrhiza 44.8g, Panax notoginseng 11.2g, Dalbergia 38.6g, adjuvant polyethylene glycol-6000 30g, according to the preparation process of embodiment 1, make the traditional Chinese medicine preparation of the present invention.

Embodiment 3

[0116] Get 77.3g of Radix Astragali, 22.8g of Salvia miltiorrhiza, 4.8g of Radix Notoginseng, 30.5g of Jiangxiang, and 28g of polyethylene glycol-6000 as an auxiliary material, and make the traditional Chinese medicine preparation of the present invention according to the preparation process of Example 1.

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Abstract

The invention relates to application of a qi-tonifying dripping pill containing radix astragali and root of red-rooted salvia to preparation of a medicament for improving myocardial fibrosis and myocardial hypertrophy. The qi-tonifying dripping pill containing radix astragali and root of red-rooted salvia is refined from active ingredients in radix astragali, root of red-rooted salvia, pseudo-ginseng and dalbergia heartwood extracted by modern technology. The invention aims to provide application of qi-tonifying dripping pill containing radix astragali and root of red-rooted salvia to preparation of the medicament for improving myocardial fibrosis and inhibiting further myocardial hypertrophy. According to the application in the invention, after generation of ventriculus sinister hypertrophy, the qi-tonifying dripping pill containing radix astragali and root of red-rooted salvia can improve myocardial fibrosis, substantially inhibit increase of wall thickness cardiac index and body mass index in ventriculus sinister diastasis, increase ejection fraction and shortening fraction of the ventriculus sinister and reduce scope of myocardial fibrosis.

Description

technical field [0001] The invention belongs to the field of medical applications, and in particular relates to the application of Qishen Yiqi dripping pills in the preparation of drugs for improving myocardial fibrosis and myocardial hypertrophy. Background technique [0002] Qishen Yiqi Dropping Pills (abbreviation: QSYQ) is a modern traditional Chinese medicine exclusively developed by Tasly Group for the treatment of cardiovascular diseases, and it is currently on the market. Qishen Yiqi Dropping Pills is a drop pill preparation refined by extracting active ingredients in Astragalus, Salvia, Sanqi, and Jiangxiang with modern technology. It is the crystallization of the combination of traditional Chinese medicine theory and current preparation technology. [0003] Qishen Yiqi Dropping Pills can significantly improve various symptoms of myocardial injury and decreased heart function. Stimulation, no obvious toxic and side effects, suitable for: chronic cardiac insufficien...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/537A61P9/00
Inventor 韩晶岩李彦川刘育英胡白和常昕
Owner TIANJIN TASLY PHARMA CO LTD
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