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Compound antagonist of animal anesthetic and application of compound antagonist

A technology of antagonists and anesthetics, applied in the field of pharmaceutical compositions, can solve problems such as damage to animal bodies, general awakening effect, toxic and side effects, and achieve the effects of large safety factor, significant awakening effect, and stable recovery.

Inactive Publication Date: 2012-03-28
NANJING AGRICULTURAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In veterinary clinical applications, single use of a certain anesthetic antagonist will produce certain toxic and side effects, damage the animal body, and the awakening effect is general

Method used

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  • Compound antagonist of animal anesthetic and application of compound antagonist
  • Compound antagonist of animal anesthetic and application of compound antagonist
  • Compound antagonist of animal anesthetic and application of compound antagonist

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0014] Dissolve the following substances in water for injection respectively, and prepare per milliliter including 1 mg of citric acid, 3.34 mg of sodium citrate, 0.9 mg of methyl paraben, 0.1 mg of propyl paraben, 0.5 mg of yohimbine hydrochloride, A mixed solution of flumazenil hydrochloride 0.2 mg was filtered, packaged and sterilized to prepare an injection.

Embodiment 2

[0016] The following substances were respectively dissolved in water for injection, and each ml was formulated to include 1 mg of citric acid, 3.34 mg of sodium citrate, 0.9 mg of methyl paraben, 0.1 mg of propyl paraben, 2.0 mg of yohimbine hydrochloride, A mixed solution of flumazenil hydrochloride 0.1 mg was filtered, packaged and sterilized to prepare an injection.

Embodiment 3

[0018] Dissolve the following substances in water for injection respectively, and prepare per milliliter including 1 mg of citric acid, 3.34 mg of sodium citrate, 0.9 mg of methyl paraben, 0.1 mg of propyl paraben, 1.0 mg of yohimbine hydrochloride, A mixed solution of 0.4 mg of flumazenil hydrochloride was filtered, packaged and sterilized to prepare an injection.

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Abstract

The invention discloses a compound antagonist of an animal anesthetic and an application of the compound antagonist, belonging to a medicine composition in the field of veterinarian. Each ml of compound antagonist comprises active ingredients of 0.5-2.0mg of Yohimbine hydrochloride and 0.1-0.4mg of flumazenil hydrochloride. The compound antagonist of the animal anesthetic has a remarkable awakening effect to an anesthetized animal, better effect compared with the single use of the Yohimbine hydrochloride or the flumazenil hydrochloride, is rapid in awakening, has no any adverse effect, is stable in recovery of circulating and breathing mechanisms, and has large safety factor and clinical application safety.

Description

technical field [0001] The invention relates to a pharmaceutical composition and its application, in particular to a compound antagonist of an animal anesthetic and its application. Background technique [0002] Narcotic antagonists refer to a class of drugs that can effectively antagonize the pharmacological effects of anesthetics. Anesthesia antagonists can effectively antagonize the inhibition of anesthetics on the central nervous system and physiological functions, reverse the adverse effects and complications of anesthetics, control the concentration and time of anesthesia, accelerate the recovery of animal physiological functions, and can be used for first aid in anesthesia overdose poisoning, thereby improving Safety and control of anesthesia. Therefore, the study of animal anesthesia antagonists is an important part of safe and effective animal anesthesia techniques. [0003] At present, the anesthetic antagonists commonly used in the veterinary field mainly includ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/5517A61K31/475A61P39/00
Inventor 侯加法韩芸婷李培德周振雷邓益锋
Owner NANJING AGRICULTURAL UNIVERSITY
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