Polycrystal substance of piperaquine phosphate and preparation method thereof

A technology of piperaquine phosphate and crystal form, applied in the field of piperaquine phosphate polymorph and its preparation, can solve the problems of easy discoloration, unstable physical and chemical properties, increase of related substances, etc., and achieves low toxicity, harm to people and the environment Friendly, easy-to-use effects
CN102558048AActive Publication Date: 2012-07-11珠海润都制药股份有限公司
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
珠海润都制药股份有限公司
Publication Date
2012-07-11

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Abstract

The invention discloses a novel polycrystal substance of piperaquine phosphate. Compared with amorphous piperaquine phosphate, the polycrystal substance of the piperaquine phosphate, which is disclosed by the invention, has better stability and better facilitates the production, the storage and the circulation of raw medicine and preparations thereof, wherein a crystal form A of the piperaquine phosphate has the best stability, the best dissolution rate and the best dissolubility. The invention further discloses a preparation method of the polycrystal substance of the piperaquine phosphate. The method has the advantages of low toxicity, people friendliness, environment friendliness, easily-controlled technological parameters, and the like, is simple to operate and is suitable for mass production.
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Description

technical field

[0001] The invention relates to a novel polymorphic form of piperaquine phosphate and a preparation method thereof. Background technique

[0002] As one of the three catastrophic diseases, malaria is caused by Plasmodium, which is mainly transmitted through mosquito bites. The main symptoms are fever, headache and vomiting. If not treated in time, malaria may be fatal. According to the World Health Organization (WHO), about 3.3 billion people worldwide are at risk of malaria, and there were about 225 million malaria cases worldwide in 2009. Malaria is particularly severe in Africa, where 709,000 of the 781,000 global malaria deaths in 2009 were in Africa. Artemisinin drugs are effective drugs for the treatment of malaria, but due to the overuse of the drug, it leads to the emergence of drug resistance. Therefore, WHO calls for stopping the use of artemisinin single-drug therapy and recommends the use of compound drugs to treat malaria. Resistance to antimal...

Claims

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