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A method for preparing hydroxyethyl starch with a molecular weight of 5.5 million

A technology of hydroxyethyl starch and molecular weight, applied in the field of medicine, can solve the problems of complex production process, strict requirements on reaction conditions and high risk, and achieve the effect of shortening the production cycle and reducing the probability of pollution

Active Publication Date: 2016-01-20
天津市灏洋生物制品科技有限责任公司
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Problems solved by technology

[0007] The present invention proposes a method for preparing hydroxyethyl starch with a molecular weight of 5.5 million, which solves the problem that ethylene oxide is used as one of the main raw materials in the prior art, which is highly dangerous, difficult to separate and purify, and the production process is relatively complicated. , the reaction conditions are very strict, and it is difficult to produce high-quality hydroxyethyl starch with an average molecular weight of 5.5 million

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  • A method for preparing hydroxyethyl starch with a molecular weight of 5.5 million

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Embodiment Construction

[0029] The following will clearly and completely describe the technical solutions in the embodiments of the present invention with reference to the accompanying drawings in the embodiments of the present invention. Obviously, the described embodiments are only some, not all, embodiments of the present invention. Based on the embodiments of the present invention, all other embodiments obtained by persons of ordinary skill in the art without creative efforts fall within the protection scope of the present invention.

[0030] A preparation method of hydroxyethyl starch with a molecular weight of 5.5 million, comprising:

[0031] Acid hydrolysis step: add hydrochloric acid and medical grade cornstarch to the container for hydrolysis reaction, and cool down for later use after the hydrolysis reaction is completed;

[0032] The step of preparing alkaline solution: add distilled water and sodium hydroxide to the container and mix to make an alkaline solution for later use;

[0033] ...

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Abstract

The invention provides a preparation method of hydroxyethyl starch with a molecular weight of 5,500,000. The preparation method comprises the following steps: an acid hydrolysis step, an alkaline solution preparation step and a hydroxyethylation step. In the hydroxyethylation step of the preparation method of the hydroxyethyl starch with the molecular weight of 5,500,000, ethylene oxide with a high risk is replaced by chloroethanol; the production process is safer; in the preparation process, distilled water is taken as a dispersion medium, and the hydroxyethylation step is directly carried out after the acid hydrolysis step, so that the production cycle is shortened and the polluting chance is reduced; activated carbon decolorization in form of 767 injection can control toxin in the hydroxyethyl starch at a low level; and the molecular weight distribution of the hydroxyethyl starch is regulated and residues and byproducts after reaction are removed by an ultrafiltration technology, so that the average molecular weight of the hydroxyethyl starch is 5.5 million and the hydroxyethyl starch is non-cytotoxic, sterile and low in fever.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to a preparation method of hydroxyethyl starch with a molecular weight of 5.5 million. Background technique [0002] Hydroxyethyl starch is obtained from the derivatization reaction of pullulan. Its chemical structure is similar to polysaccharides and glycogen in the body, and its side effects are smaller than plasma substitutes such as gum arabic and sodium alginate. Moreover, due to the existence of the hydroxyethyl group, on the one hand, it reduces the degradation rate of hydroxyethyl starch by amylase in the body, making it have a certain anti-shock effect; Solubility in order to prepare a solution of a certain concentration for clinical use. Therefore, hydroxyethyl starch solution is currently a commonly used plasma substitute in clinical practice. According to the molecular weight and the degree of substitution of hydroxyethyl starch, hydroxyethyl starch can be divided int...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08B31/12
Inventor 高旭
Owner 天津市灏洋生物制品科技有限责任公司
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