An ancestral serine protease coagulation cascade exerts a novel function in early immune defense

A protein and protein technology, applied in the direction of peptide/protein components, cardiovascular system diseases, non-central analgesics, etc.

Inactive Publication Date: 2013-05-01
CSL BEHRING GMBH +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0007] However, it has not been shown that bacteria can also be immobilized in vivo in this way

Method used

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  • An ancestral serine protease coagulation cascade exerts a novel function in early immune defense
  • An ancestral serine protease coagulation cascade exerts a novel function in early immune defense
  • An ancestral serine protease coagulation cascade exerts a novel function in early immune defense

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Embodiment Construction

[0019] Phylogenetically conserved serine protease cascades play important roles in invertebrate and vertebrate immunity. The mammalian coagulation system dates back about 400 million years and it shares homology with ancestral serine protease cascades involved in, for example, Toll receptor signaling in insects and the release of antimicrobial peptides during hemolymph clotting. The present invention shows that induction of coagulation by bacteria leads to immobilization of microorganisms within the clot and production of antimicrobial activity. In this way, the coagulation cascade of ancestral serine proteases has a new function in early immune defense. Trapping is mediated by cross-linking bacteria with fibrin fibers through the action of Factor XIII (FXIII), an evolutionarily conserved transglutaminase. Infected FXIII - / - Mice showed signs of severe pathological inflammation, whereas treatment of wild-type animals with FXIII inhibited bacterial dissemination. Bacterial k...

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Abstract

The present invention relates to blood coagulation factor XIII (FXIII) for treatment and / or prevention of an infection by a microorganism and / or the symptoms associated with said infection, a pharmaceutical composition comprising a pharmaceutically effective amount of said FXIII, a method for the manufacture of a medicament comprising a pharmaceutically effective amount of said FXIII, and a method of treatment comprising administering to a patient in need a pharmaceutically effective amount of said FXIII.

Description

field of invention [0001] The present invention relates to blood coagulation factor XIII (FXIII), which is used for treating and / or preventing infection by microorganisms and / or symptoms associated with said infection; a pharmaceutical composition comprising said FXIII in a pharmaceutically effective amount; for the preparation of A method of medicament comprising a pharmaceutically effective amount of said FXIII; and a method of treatment comprising administering a pharmaceutically effective amount of said FXIII to a patient in need thereof. [0002] Numerous documents are referenced throughout this specification, including patent applications and manufacturer's manuals. The disclosures of these documents, when not considered material to the patentability of this invention, are hereby incorporated by reference in their entireties. More specifically, all references are incorporated by reference to the same extent as if each individual document was specifically and individuall...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K38/45A61P31/00
CPCA61K38/45A61P1/00A61P1/16A61P9/00A61P11/00A61P13/00A61P13/12A61P17/00A61P21/00A61P25/00A61P25/04A61P25/06A61P29/00A61P31/00A61P31/04
Inventor H·赫瓦德U·特奥博尔德T·卢夫M·默格林G·迪肯内特
Owner CSL BEHRING GMBH
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