Traditional Chinese medicinal recipe for inhibiting streptococcus

A technology of Chinese herbal medicine and streptococcus, which is applied in the direction of medical formulas, antibacterial drugs, and medical preparations containing active ingredients, etc. It can solve problems such as deterioration of the breeding environment, imbalance of ecological balance, and threats to eaters, and achieves a simple production process. Produce drug-resistant, inexpensive effects

Inactive Publication Date: 2015-05-20
NINGBO UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, long-term abuse of drugs or antibiotics will cause water environment pollution, which will lead to deterioration of the breeding environment, imbalance of ecological balance, and bacteria will develop drug resistance, and drug residues will pose a potential threat to consumers

Method used

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  • Traditional Chinese medicinal recipe for inhibiting streptococcus
  • Traditional Chinese medicinal recipe for inhibiting streptococcus

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0011] The present invention is a Chinese herbal medicine formula for inhibiting streptococci. The following 34 Chinese herbal medicines have different degrees of antibacterial effects on streptococci.

[0012] First, pomegranate peel, catechu and schisandra have the strongest in vitro bacteriostatic effects on streptococci, with the minimum inhibitory concentration (MIC) reaching 6.25mg / ml; secondly, ebony and papaya have strong bacteriostatic effects on streptococci, the smallest Inhibitory concentration (MIC) reached 12.5mg / ml. Sanguis frangipani also has a certain bacteriostatic effect on streptococci, with a MIC of 25mg / ml; raspberry, myrobalan, araceae and cassia seed have an in vitro bacteriostatic effect on streptococci Weak, with a MIC of 50mg / ml; alum, crane louse, tiger-stripe slices, violet, rhubarb, myrrh, licorice, forsythia, gentian, houttuynia, wormwood, sophora flavescens, torreya, angelica The MIC for the in vitro antibacterial effect of peony, Radix Paeoniae Al...

Embodiment 2

[0016] The present invention is a Chinese herbal medicine formula for inhibiting streptococcus. The Chinese herbal medicine is composed of the following raw materials and weight ratios: pomegranate peel, catechu, schisandra and ebony are mixed in a weight ratio of 1:1:2:2. The results show that the formula has a significant antibacterial effect on Streptococcus, which is more effective than single medicine and other combinations of Chinese herbal compound formulas. The minimum inhibitory concentration MIC is 2.34mg / ml. The minimum inhibitory concentration MIC of the Chinese herbal compound formula of pomegranate peel, catechu, schisandra and ebony in a weight ratio of 1:1:1:1 is 6.25mg / ml, pomegranate peel, catechu, schisandra and ebony The minimum inhibitory concentration MIC of the Chinese herbal compound formula mixed at a weight ratio of 8:2:4:1 is 11.42mg / ml, none of which has the best antibacterial effect.

Embodiment 3

[0018] In Vitro Bacteriostatic Test of Chinese Herbal Medicine Against Streptococcus

[0019] 1. Selection of Chinese herbal medicine and preparation of its liquid

[0020] The 86 Chinese herbal medicines selected in this study were all purchased from Ningbo Beijing Tongrentang Pharmacy. Schisandra, Chinese gallnut, ebony plum, Weilingxian, catechu, Dioscorea vulgaris, Violet dicer, Alum, Prunella vulgaris, Goose not eaten, Myrobalan meat, Sago leaves, Ley reed seeds, Cassia, Papaya, Isatis indigotica, Coptis, Senecio, aloe, male clove, Chinese tallow, wormwood, polygonum cuspidatum, crane louse, gentian, snake berry, mango leaf, forsythia, myrrh, rhubarb, peran, torreya, Yinchen, phellodendron, Wuyu, Andrographis , Suzi, Honeysuckle, Purslane, Astragalus, Licorice, Araceae, Artemisia annua, Lobelia, White peony root, Acorus calamus, Angelica dahurica, Laisi, Aster, Oldenlandia diffusa, Houttuynia cordata, Sophora flavescens, Dandelion, Shouwu, Atractylodes, Atractylodes, Perilla...

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Abstract

The invention discloses a traditional Chinese medicinal recipe for inhibiting streptococcus. The recipe is characterized by comprising at least one of pericarpium granati, catechu, fructus schisandrae chinensis, chaenomeles speciosa, fructus mume, radix sanguisorbae, fructus rubi, terminalia chebula retz, rhizoma arisaematis, semen cassiae, aluminis usti, fructus carpesii, reynoutria japonica slice, herba violae, radix et rhizoma rhei, myrrha, radix glycyrrhizae, fructus forsythiae, gentiana scabra bunge, herba houttuyniae, folium artemisiae argyi, radix sophorae flavescentis slice, semen torreyae, radix angelicae dahuricae, white paeony root, coptis chinensis franch, flos caryophyllata, humulus lupulus, anemone chinensis, rhizoma atractylodis, radix scutellaria, radix clematidis, radix curcumae and cortex phellodendri chinensis, wherein a recipe which is formed by mixing the pericarpium granati, the catechu, the fructus schisandrae chinensis and the fructus mume according to the mass ratio of 1:1:2:2 has an optimal antibacterial effect. The recipe has the advantages of naturality, no toxity and residues, no tolerance and low price.

Description

Technical field [0001] The invention relates to a Chinese herbal medicine formula, in particular to a Chinese herbal medicine formula for inhibiting streptococcus. Background technique [0002] At present, fish streptococcus disease has become a worldwide disease, which has caused huge economic losses to the world aquaculture industry. Streptococcus agalactiae in the genus Streptococcus ( Streptococcus agalactiae ) And Streptococcus dolphin ( Streptococcus iniae ) Is the main pathogen causing fish diseases. It is estimated that the global economic loss of fish caused by dolphin streptococcus alone has exceeded 150 million US dollars each year, and streptococcus has become one of the major fish pathogens in the world. Streptococcus can infect a variety of marine and freshwater aquaculture fish (such as Japanese flounder, eel, rainbow trout, tilapia, tube basket fish, yellowtail, Japanese flounder, flat fish, bamboo gate fish, red fin oriental pure, sea bream, silver Salmon, un...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/9066A61K36/8884A61K36/86A61K36/78A61K36/756A61K36/739A61K36/736A61K36/732A61K36/73A61K36/718A61K36/716A61K36/71A61K36/708A61K36/704A61K36/634A61K36/61A61K36/57A61K36/539A61K36/515A61K36/489A61K36/484A61K36/482A61K36/48A61K36/328A61K36/284A61K36/282A61K36/28A61K36/234A61K36/232A61K36/185A61K36/13A61K33/06A61P31/04
Inventor 龚一富王何瑜张文青章丽童丽娟赵群芬
Owner NINGBO UNIV
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