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Purpose of phencynonate hydrochloride for treating or relieving myocardial damage induced by myocardial ischemia reperfusion and pharmaceutical compositions including phencynonate hydrochloride

A technology of phencyclonyl hydrochloride and myocardial ischemia, which can be used in drug combinations, medical preparations containing active ingredients, cardiovascular system diseases, etc., and can solve problems such as injury and ischemia-reperfusion injury

Active Publication Date: 2013-06-05
INST OF PHARMACOLOGY & TOXICOLOGY ACAD OF MILITARY MEDICAL SCI P L A
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, reperfusion is considered a double-edged sword, causing more serious injury than ischemia alone, so-called ischemia-reperfusion injury

Method used

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  • Purpose of phencynonate hydrochloride for treating or relieving myocardial damage induced by myocardial ischemia reperfusion and pharmaceutical compositions including phencynonate hydrochloride
  • Purpose of phencynonate hydrochloride for treating or relieving myocardial damage induced by myocardial ischemia reperfusion and pharmaceutical compositions including phencynonate hydrochloride
  • Purpose of phencynonate hydrochloride for treating or relieving myocardial damage induced by myocardial ischemia reperfusion and pharmaceutical compositions including phencynonate hydrochloride

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] Phencynonate Hydrochloride Injection

[0021]

[0022]

[0023] Preparation method: Weigh 200g of phencyclonyl hydrochloride, put it in a 2000ml measuring bottle, add an appropriate amount of water for injection to dissolve, add 40g of sodium bisulfite, shake to dissolve, add water for injection to 2000ml, shake well, add hydrochloric acid Adjust the pH to pH 4 and shake well. Filter with a 0.2 μm microporous membrane. Filled in 2ml ampoules, 1000 ampoules in total. Sterilize by flowing steam (110°C, 15 minutes), check the clarity, and obtain it.

Embodiment 2

[0025] Phencynonate Hydrochloride Tablets

[0026]

[0027] Preparation method: 300 mg of phencyclonyl hydrochloride, 25 mg of magnesium stearate, 50 mg of sodium carboxymethylcellulose and 125 mg of starch were mixed, and compressed by a tablet machine to obtain a 500 mg tablet.

Embodiment 3

[0029] Phencynonate Hydrochloride Capsules:

[0030] Phencynonyl Hydrochloride 200g

[0031] Starch 400g

[0032] A total of 1000 capsules were made, and each capsule contained 200 mg of the main drug.

[0033] Preparation method: dry 400g of starch first, pass through a 120-mesh sieve, then mix it with phencyclonyl hydrochloride evenly, pass through a 120-mesh sieve twice, mix well, and fill it into hard capsules to obtain the product.

[0034] In the process of evaluating the pharmacodynamics of phencyclonyl hydrochloride in treating or alleviating myocardial injury induced by myocardial ischemia-reperfusion, rats and rabbits are used as model animals. In order to objectively evaluate the effect of drug treatment, this study successively established experimental animal models of myocardial injury induced by myocardial ischemia-reperfusion in rats and rabbits, and has clear therapeutic effects on myocardial injury induced by myocardial ischemia-reperfusion. The drug-verapa...

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Abstract

The invention relates to a function of phencynonate hydrochloride in preparing medicine for treating or relieving myocardial damage induced by myocardial ischemia reperfusion. In a myocardial ischemia reperfusion damage animal model of a rat or a rabbit, the phencynonate hydrochloride can obviously restrain the myocardial damage caused by the myocardial ischemia reperfusion, and the function is basically similar to positive therapeutic verapamil and is free of side effects of low blood pressure, slowing of heart rate of the verapamil.

Description

technical field [0001] The invention relates to the use of phencyclonyl hydrochloride in the preparation of medicines for treating or alleviating myocardial injury induced by myocardial ischemia-reperfusion and the pharmaceutical composition containing it. Background technique [0002] Phencynonate hydrochloride, 2′-cyclopentyl-2′-phenyl-2′-hydroxyacetic acid-9α-[3-methyl-3-azabicyclo(3.3.1)nonyl]ester salt acid salt) as shown in the structure of the following formula (I), is a selective anticholinergic drug. It is clinically used to prevent and treat various motion sickness such as motion sickness, seasickness and airsickness. Chinese patent (CN1089838A) and U.S. patent (US6028198) disclose the purposes of phencyclonyl hydrochloride as anti-motion sickness (motion sickness, boat, machine etc.) medicine. Chinese patent (CN97125424.9), British patent (GB2297255) and Spanish patent (ES549796A) disclose the preparation method of phencyclonyl hydrochloride. [0003] [000...

Claims

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Application Information

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IPC IPC(8): A61K31/439A61P9/10
Inventor 王永安李万华骆媛张谦刘艳芹关雷
Owner INST OF PHARMACOLOGY & TOXICOLOGY ACAD OF MILITARY MEDICAL SCI P L A
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