Method for extracting steroidal compounds from Scapharca subcrenata

A technology of steroidal compounds and extracts, applied in the field of marine natural product chemistry, can solve the problems of less research on anti-insect activity, and achieve the effect of simple preparation method, low pollution and simple operation
CN103265598BInactive Publication Date: 2015-03-04广西海洋研究所有限责任公司
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
广西海洋研究所有限责任公司
Publication Date
2015-03-04
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention discloses a method for extracting steroidal compounds from Scapharca subcrenata. Currently, researches on Scapharca subcrenata are mostly focused on active polysaccharides, polypeptides, proteins and the like, and no technique for extracting the steroidal compounds from Scapharca subcrenata is disclosed yet at present. According to the method, by carrying out the technical steps of: (1) extracting alcohol-soluble extractives from the Scapharca subcrenata, (2) preparing Scapharca subcrenata extractants, (3) extracting the steroidal compounds, (4) analyzing physicochemical properties and spectrum data of the three pure compounds, and the like, normal butanol phases in extraction liquid in the alcohol-soluble extractives are separated and purified to obtain cholesterol, cholestanol and progesterone; after being tested, all the three steroidal compounds have good activities in killing of artemia, the fatality rates to artemia respectively are 65.0%, 58.3% and 60% when the concentrations are 50 micrograms per microliter, and the artemia killing rates rise with the increase of concentrations, so that the concentration dependency is expressed; and the development period of a new medicine can be greatly shortened by utilizing the method, and the method is significant to research and development of the new medicine.
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Description

technical field

[0001] The invention relates to a method for extracting steroidal compounds from cockles, belonging to the field of marine natural product chemistry. Background technique

[0002] Hair clam (Scapharca subcrenata), also known as "hair clam, hemp clam", is a mollusc Phylumbranchia Scapharca clam family. It is distributed in the coastal areas of China, Korea and Japan, especially in the Bohai Sea and the East China Sea. Clams have high nutritional and medicinal value. They have the effects of resolving phlegm, softening firmness, dispelling blood stasis, and eliminating stagnation. They can treat diseases such as phlegm accumulation, stomach pain, noise, acid regurgitation, scarring, scrofula, and dental malnutrition. It is now widely used In the clinical treatment of gastric and duodenal ulcers, there are medicinal records in "Shen Nong's Materia Medica" and the main herbal medicines of the past dynasties. It is used in folks for anti-tumor, anti-anemia and ant...

Claims

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