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Method for determination of phthalates

A technology of ester compounds and phthalic acid, applied in measuring devices, instruments, scientific instruments, etc., can solve problems affecting accuracy, background interference, etc., and achieve the effect of eliminating interference

Active Publication Date: 2015-07-29
JIANGSU ENVIRONMENTAL MONITORING CENT
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] However, when entering the instrument analysis step, since some of the pipelines of the instrument itself are made of plastic materials, these pipelines cannot be replaced in time in a conventional laboratory, so it is inevitable that the determination of phthalates will bring serious problems. Background interference, there are still relatively few plastic pipelines in gas chromatography, and most of the mobile phase pipelines in liquid chromatography systems are made of polytetrafluoroethylene. Especially when the liquid mass spectrometry system is used, because this technique has high sensitivity, it is very suitable for the detection of trace compounds, and the introduction of interference in the pipeline makes the phthalates in the blank sample Has a large response value, which greatly affects the accuracy of the actual sample determination

Method used

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  • Method for determination of phthalates

Examples

Experimental program
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Embodiment 1

[0026] A method for determining phthalates, comprising the following steps: the mobile phase is pressurized by a liquid chromatography pump 1, filtered through a filter 2, and then enters an anti-interference device for determining phthalates ;

[0027] After being adsorbed by the anti-interference device, the mobile phase passing through the adsorption column 3 pushes the sample to be tested into the liquid mass spectrometry system for analysis.

[0028] One end of the above anti-interference device is connected in series with the liquid chromatography pump 1 and filter 2 of the liquid chromatography system through the connecting pipe 5, and the other end of the anti-interference device is connected with the six-way valve 6 of the liquid chromatography system through the connecting pipe 5 connected, the anti-jamming device includes an adsorption column 3 with adsorption and distribution, and also includes an adsorption layer composed of adsorption fillers located in the adsor...

Embodiment 2

[0037] The difference from Example 1 is that in Example 2, the column length of the adsorption column 3 is 100 mm, the inner diameter is 6 mm, the pore diameter of the sieve plate 9 is 3 μm, and the particle size of the cross-linked styrene-divinylbenzene polymer matrix 5 is 10 μm .

Embodiment 3

[0039] The difference from Example 1 is that in Example 3, the column length of the adsorption column 3 is 60 mm, the inner diameter is 5 mm, the pore diameter of the sieve plate 9 is 2 μm, and the particle size of the cross-linked styrene-divinylbenzene polymer matrix 5 is 6 μm .

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Abstract

The present invention belongs to the field of organic compounds detection, specifically to a method for measuring phthalate acid esters. The method comprises the following steps: mobile phase is pressurized by a liquid chromatographic pump, filtered by a filter, and then put into an anti jamming unit for phthalate esters determination; being adsorbed by the anti jamming unit, the mobile phase passed by an adsorption column pushes the sample to be measured into an LC-MS system for analysis. Said method for determination of phthalate acid esters is adopted; by connecting the adsorption column with absorption and distribution effect between a six-way valve of a liquid chromatography system and the liquid chromatographic pump / filter, the phthalate esters introduced in the pipeline are remained in the adsorption column in an extent when the mobile passes through the adsorption column, therefore a time drift of remain time of the target compounds contained in samples in reality is generated, and inteference is eliminated.

Description

technical field [0001] The invention belongs to the field of organic compound detection, and in particular relates to a method for measuring phthalate compounds. Background technique [0002] Phthalate acid esters (PAEs) are a class of commonly used industrial organic compounds, mainly used as plastic plasticizers, and the addition amount in PVC plastic products reaches 20%-50%. It is connected with polyolefin plastic molecules by hydrogen bonds or van der Waals forces, and each has relatively independent chemical properties, so it is very easy to transfer into water, soil, and atmospheric environments. In the past, it was believed that PAEs had low toxicity, so they were a colorless and odorless liquid plasticizer in industrial production. However, recent studies have found that PAEs have estrogenic characteristics and anti-androgen biological effects, which will interfere with animals and humans. The normal endocrine function of the human body causes the disorder of the...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N30/26G01N30/50
Inventor 赵永刚张蓓蓓章勇
Owner JIANGSU ENVIRONMENTAL MONITORING CENT