Folic acid - ramipril combination: cellprotective, neuroprotective and retinoprotective ophtalmologic compositions

A composition and technology of folic acid, applied in the direction of drug combination, nervous system diseases, carbohydrate active ingredients, etc., can solve problems such as physiological vision loss, retinal dystrophy, etc.

Inactive Publication Date: 2013-10-02
拉乌夫·雷基克
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] 4. Hereditary retinal dystrophies (including pigmentary retinopathy and Stargardt (Stargardt) macular degeneration);
[0016] 11. Physiological vision loss

Method used

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  • Folic acid - ramipril combination: cellprotective, neuroprotective and retinoprotective ophtalmologic compositions
  • Folic acid - ramipril combination: cellprotective, neuroprotective and retinoprotective ophtalmologic compositions
  • Folic acid - ramipril combination: cellprotective, neuroprotective and retinoprotective ophtalmologic compositions

Examples

Experimental program
Comparison scheme
Effect test

Embodiment approach

[0212] Point 1. A method of maintaining or improving the vision and / or field of vision of a patient in need of such treatment. The method comprises the steps of: administering a pharmaceutical composition comprising ramipril (an angiotensin converting enzyme inhibitor) and folic acid. This medicine can maintain or improve vision and field of vision.

[0213] Point 2. The method according to point 1, wherein the drug is a cytoprotective, neuroprotective and / or retinal protective agent.

[0214] Point 2a. Method according to point 1, wherein said drug is combined with one or several compounds selected from: L-arginine, H4b, vitamin B6, vitamin B12, vitamin C, omega-3 fatty acids , magnesium, potassium, glucose, NSAIDs, steroidal anti-inflammatory agents, and amino acids such as leucine (especially acetyl-leucine), beta-blockers, epinephrine, norepinephrine hormones, alpha-adrenoceptor agonists, and anti-VEGF agents.

[0215] Point 3. The method according to point 1, wherein t...

Embodiment

[0231] Embodiment: clinical observation

[0232] In the clinical case disclosed below, the active ingredients, in particular ramipril and folic acid, were administered continuously (i.e. at least once a day), 1.25 mg of ramipril was administered orally per day and topically 5mg folic acid.

[0233] The clinical observations disclosed below are of course provided by way of example only and do not limit the invention in any way. Of note, the same observations were made in "normal" patients (particularly elderly patients over 60 years of age) without any ophthalmic pathology who were administered the drug; these patients noted their visual acuity Improvement, in particular, that older people regain the average sensitivity they had when they were very young.

[0234] Glaucoma and glaucomatous neuropathy: Combination administration of ramipril and folic acid, either in oral or topical form, caused improvement in visual function (vision or field of view) and reduction in intraocu...

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Abstract

The invention relates to a cellprotective, neuroprotective and retinoprotective composition. In an embodiment of the invention, said composition comprises (i) Ramipril or Ramiprilate and (ii) folic acid. The composition of the invention can be used, in particular, for the prevention of loss of vision, or even for improving visual acuity and visual field in normal subjects, as well as for treating ophthalmologic pathologies, in particular: glaucoma, diabetic retinopathy, age related macular degeneration, hereditary dystrophy of the retina, uveitis, ammetropia (myopia, presbyopia). This combination of active principles could also be used in general conditions for treating general pathologies (cancer...).

Description

technical field [0001] The present invention relates to a composition, in particular, a cytoprotective, neuroprotective and retinal protective composition, which is particularly suitable for maintaining or improving visual function (sight or visual field). In an embodiment of the present invention, the composition comprises (i) Ramipril or Ramipril and (ii) folic acid. Background technique [0002] The invention also relates to the use of said composition for the prophylaxis or treatment of different types of diseases or disorders, in particular cancers or ophthalmic diseases or disorders involving the chorioretinal and / or optic nerve, which lead to progressive loss of vision (vision and / or visual field ). [0003] Effects on vision have been observed, especially in glaucoma, macular degeneration, hereditary retinal diseases, myopia, presbyopia, uveitis and diabetic retinopathy. [0004] In an embodiment of the present invention, angiotensin-converting enzyme inhibitor (su...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/00A61K31/198A61K31/20A61K31/375A61K31/403A61K31/505A61K31/519A61K31/70A61K31/714A61K33/06A61K33/14
CPCA61K9/0048A61K31/198A61K31/20A61K31/375A61K31/403A61K31/405A61K31/4415A61K31/4985A61K31/505A61K31/519A61K31/70A61K31/7004A61K31/714A61K33/06A61K33/14A61K45/06A61P3/06A61P3/10A61P9/10A61P9/12A61P25/00A61P25/16A61P25/28A61P27/02A61P27/04A61P27/06A61P27/10A61P27/14A61P29/00A61P31/04A61P31/12A61P31/18A61P33/00A61P35/00A61P37/02A61K2300/00
Inventor 拉乌夫·雷基克
Owner 拉乌夫·雷基克
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